Peter. Vogel, et.al., Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions., PloS one, 2009, 4

http://rdf.ncbi.nlm.nih.gov/pubmed/19119317

Peter. Vogel, et.al., Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions., PloS one, 2009, 4

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833931
• Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833933

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased double-positive T cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0005092I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• premature death_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002083I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal urothelium morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0003630I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal osteoclast morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0004982I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• thymus medulla hyperplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0013591I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• increased CD4-positive, alpha beta T cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0008074I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal lymph node morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002339I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• thymus cortex hypoplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0000711I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1GtOST58278Lex
• postnatal growth retardation_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0001732I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• thymus medulla hyperplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0013591I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1GtOST58278Lex
• abnormal definitive hematopoiesis_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002123I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal lymphopoiesis_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002401I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased pre-B cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0008209I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• increased osteoclast cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0004984I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased T cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0005018I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal immune system organ morphology_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0002722I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• lymph node hypoplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0008101I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal myocardial fiber morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000278I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• increased CD8-positive, alpha-beta T cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0008078I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased lymphocyte cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0005016I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• increased monocyte cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000220I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased CD4-positive, alpha beta T cell number_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0008075I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• abnormal small intestine morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000496I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal renal/urinary system morphology_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0000516I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• decreased T cell number_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0005018I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• thymus cortex hypoplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000711I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal trabecular bone morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000130I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal heart morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000266I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased B cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0005017I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• thick pulmonary interalveolar septum_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0001179I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased neutrophil cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000222I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased body weight_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0001262I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• lymphoid hypoplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002223I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased lymphocyte cell number_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0005016I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• increased granulocyte number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000322I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal lymph node morphology_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0002339I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• abnormal immune system organ morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0002722I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1GtOST58278Lex
• increased single-positive T cell number_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0008082I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• abnormal osteoclast morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0004982I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1GtOST58278Lex
• abnormal pulmonary alveolus morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002270I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• abnormal thymus lobule morphology_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0002367I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• abnormal spleen periarteriolar lymphoid sheath morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002358I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased B cell number_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0005017I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• thymus hypoplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0001823I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased CD8-positive, alpha-beta T cell number_Sgpl1<tm1(SGPL1)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0008079I129S4SvJae129S5SvEvBrdC57BL6JSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1Lex
• abnormal bone marrow morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0002397I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex
• decreased T cell number_Sgpl1<Gt(OST58278)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0005018I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1GtOST58278Lex
• abnormal urinary bladder urothelium morphology_Sgpl1<Gt(OST58278)Lex>/Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/0000540I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1tm1SGPL1LexSgpl1tm1SGPL1LexSgpl1GtOST58278Lex
• spleen hypoplasia_Sgpl1<Gt(OST58278)Lex>/Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/0000694I129S5SvEvBrdC57BL6JSgpl1GtOST58278LexSgpl1GtOST58278LexSgpl1GtOST58278Lex

class

http://purl.org/net/cito/citesAsAuthority

• Sgpl1<Gt(OST58278)Lex>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833931
• Sgpl1<tm1(SGPL1)Lex>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833933