Olivier. Ayrault, et.al., Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma., Molecular cancer research : MCR, 2009, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/19147535

Olivier. Ayrault, et.al., Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma., Molecular cancer research : MCR, 2009, 7

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cerebellar molecular layer_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0000889I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased rhabdomyosarcoma incidence_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002036I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• increased gastrointestinal tumor incidence_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0010279I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased gastrointestinal tumor incidence_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0010279I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• abnormal cerebellar molecular layer_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0000889I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• increased tumor incidence_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002020I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• increased medulloblastoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0006283I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased lymphoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0012431I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• abnormal cerebellar molecular layer_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0000889I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• premature death_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• increased tumor incidence_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002020I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased hemangiosarcoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0003667I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• abnormal cerebellar molecular layer_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0000889I129S1Sv129X1SvJC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdPtch1tm1MpsPtch1Cdkn2ctm1BbdPtch1Ptch1tm1Mps
• premature death_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased hemangiosarcoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0003667I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• increased rhabdomyosarcoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002036I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased medulloblastoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0006283I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• premature death_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• increased rhabdomyosarcoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002036I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• increased lymphoma incidence_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0012431I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• hydroencephaly_Cdkn1b<tm1Mlf>/Cdkn1b<tm1Mlf>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0001891I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1btm1MlfPtch1tm1MpsPtch1Cdkn1btm1MlfPtch1tm1MpsPtch1
• increased tumor incidence_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• increased gastrointestinal tumor incidence_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0010279I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• increased hemangiosarcoma incidence_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0003667I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• hydroencephaly_Cdkn1b<tm1Mlf>/Cdkn1b<+>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0001891I129S1Sv129S4SvJaeSor129X1SvJC57BL6Cdkn1btm1MlfCdkn1bPtch1tm1MpsPtch1Ptch1Ptch1tm1MpsCdkn1bCdkn1btm1Mlf
• increased lymphoma incidence_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0012431I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• increased medulloblastoma incidence_Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0006283I129S1Sv129X1SvJC57BL6Ptch1tm1MpsPtch1Ptch1Ptch1tm1Mps
• increased medulloblastoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>,Ptch1<tm1Mps>/Ptch1<+>
  http://metadb.riken.jp/0006283I129S1Sv129X1SvJC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdPtch1tm1MpsPtch1Cdkn2ctm1BbdPtch1Ptch1tm1Mps

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hemangiosarcoma incidence in RBRC06251
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1017518
• increased gastrointestinal tumor incidence in RBRC06251
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1017520
• abnormal cerebellar molecular layer in RBRC06251
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1017517
• premature death in RBRC06251
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1017515
• increased lymphoma incidence in RBRC06251
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1017521