Erin R P. Shull, et.al., Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS., Genes & development, 2009, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/19171781

Erin R P. Shull, et.al., Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS., Genes & development, 2009, 23

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nbn<tm3Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831174
• Lig4<tm1Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831168

class

http://purl.org/net/cito/citesAsAuthority

• Nbn<tm3Jpt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831174
• Lig4<tm1Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831168

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased cellular sensitivity to ionizing radiation_Lig4<tm1Icrf>/Lig4<tm1Icrf>,Mre11a<tm1Jpt>/Mre11a<tm1Jpt>
  http://metadb.riken.jp/0004228I129129S7SvEvBrdLig4tm1IcrfLig4tm1IcrfMre11atm1JptMre11atm1JptMre11atm1JptLig4tm1Icrf
• ataxia_Atm<tm1Pmc>/Atm<tm1Pmc>,Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393I129S1SvImJC57BL6SJLAtmtm1PmcAtmtm1PmcLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnAtmtm1PmcLig4tm1Pmc
• perinatal lethality, complete penetrance_Lig4<tm1Icrf>/Lig4<tm1Icrf>,Nbn<tm2.1Jpt>/Nbn<tm2.1Jpt>
  http://metadb.riken.jp/0011089I129129SvLig4tm1IcrfLig4tm1IcrfNbntm21JptNbntm21JptNbntm21JptLig4tm1Icrf
• abnormal DNA repair_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008058I129S1SvImJC57BL6SJLLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnLig4tm1Pmc
• ataxia_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Mre11a<tm1Jpt>/Mre11a<tm1Jpt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393I129S1SvImJ129S7SvEvBrdC57BL6SJLLig4tm1PmcLig4tm1PmcMre11atm1JptMre11atm1JptTgNescre1Kln0Mre11atm1JptLig4tm1PmcTgNescre1Kln
• perinatal lethality_Atm<tm1Pmc>/Atm<tm1Pmc>,Lig4<tm1Icrf>/Lig4<tm1Icrf>
  http://metadb.riken.jp/0002081I129Atmtm1PmcAtmtm1PmcLig4tm1IcrfLig4tm1IcrfLig4tm1IcrfAtmtm1Pmc
• decreased cellular sensitivity to ionizing radiation_Atm<tm1Pmc>/Atm<tm1Pmc>,Lig4<tm1Icrf>/Lig4<tm1Icrf>
  http://metadb.riken.jp/0004228I129Atmtm1PmcAtmtm1PmcLig4tm1IcrfLig4tm1IcrfLig4tm1IcrfAtmtm1Pmc
• decreased brain size_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000774I129S1SvImJC57BL6SJLLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnLig4tm1Pmc
• prenatal lethality, complete penetrance_Lig4<tm1Icrf>/Lig4<tm1Icrf>,Nbn<tm1Jpt>/Nbn<tm1Jpt>
  http://metadb.riken.jp/0011091I129129S7SvEvBrdLig4tm1IcrfLig4tm1IcrfNbntm1JptNbntm1JptNbntm1JptLig4tm1Icrf
• decreased cellular sensitivity to ionizing radiation_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>
  http://metadb.riken.jp/0004228I129S7SvEvBrdMre11atm1JptMre11atm1JptMre11atm1Jpt
• neonatal lethality, complete penetrance_Lig4<tm1Icrf>/Lig4<tm1Icrf>,Mre11a<tm1Jpt>/Mre11a<tm1Jpt>
  http://metadb.riken.jp/0011087I129129S7SvEvBrdLig4tm1IcrfLig4tm1IcrfMre11atm1JptMre11atm1JptMre11atm1JptLig4tm1Icrf
• abnormal brain development_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Nbn<tm1Jpt>/Nbn<tm1Jpt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000913I129S1SvImJ129S7SvEvBrdC57BL6SJLLig4tm1PmcLig4tm1PmcNbntm1JptNbntm1JptTgNescre1Kln0Lig4tm1PmcNbntm1JptTgNescre1Kln
• microcephaly_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Nbn<tm1Jpt>/Nbn<tm1Jpt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000433I129S1SvImJ129S7SvEvBrdC57BL6SJLLig4tm1PmcLig4tm1PmcNbntm1JptNbntm1JptTgNescre1Kln0Lig4tm1PmcNbntm1JptTgNescre1Kln
• decreased cellular sensitivity to ionizing radiation_Nbn<tm3Jpt>/Nbn<tm3Jpt>
  http://metadb.riken.jp/0004228I129SvNbntm3JptNbntm3JptNbntm3Jpt
• decreased brain weight_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002175I129S1SvImJC57BL6SJLLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnLig4tm1Pmc
• microcephaly_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000433I129S1SvImJC57BL6SJLLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnLig4tm1Pmc
• ataxia_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393I129S1SvImJC57BL6SJLLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnLig4tm1Pmc
• abnormal brain development_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000913I129S1SvImJC57BL6SJLLig4tm1PmcLig4tm1PmcTgNescre1Kln0TgNescre1KlnLig4tm1Pmc
• decreased brain weight_Lig4<tm1Pmc>/Lig4<tm1Pmc>,Nbn<tm1Jpt>/Nbn<tm1Jpt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002175I129S1SvImJ129S7SvEvBrdC57BL6SJLLig4tm1PmcLig4tm1PmcNbntm1JptNbntm1JptTgNescre1Kln0Lig4tm1PmcNbntm1JptTgNescre1Kln