Arne. Zibat, et.al., Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts., Carcinogenesis, 2009, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/19321799

Arne. Zibat, et.al., Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts., Carcinogenesis, 2009, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptch1<tm1.1Hahn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5447563

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Ptch1<tm1Hahn>/Ptch1<tm1Hahn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002020I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26SorPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26Sor
• increased tumor incidence_Ptch1<tm1.1Hahn>/Ptch1<+>
  http://metadb.riken.jp/0002020I129BALBcC57BL6FVBNPtch1tm11HahnPtch1Ptch1tm11HahnPtch1
• increased medulloblastoma incidence_Ptch1<tm1.1Hahn>/Ptch1<+>
  http://metadb.riken.jp/0006283I129BALBcC57BL6FVBNPtch1tm11HahnPtch1Ptch1tm11HahnPtch1
• increased fibroma incidence_Ptch1<tm1Hahn>/Ptch1<+>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003580I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1GtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnPtch1GtROSA26SorPtch1tm1Hahn
• increased basal cell carcinoma incidence_Ptch1<tm1Hahn>/Ptch1<tm1Hahn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004208I129P2OlaHsd129S1Sv129X1SvJBALBcC57BL6Ptch1tm1HahnPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnGtROSA26SorPtch1tm1Hahn
• increased tumor incidence_Ptch1<tm1Hahn>/Ptch1<tm1Hahn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002020I129P2OlaHsd129S1Sv129X1SvJBALBcC57BL6Ptch1tm1HahnPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnGtROSA26SorPtch1tm1Hahn
• premature death_Ptch1<tm1Hahn>/Ptch1<+>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1GtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnPtch1GtROSA26SorPtch1tm1Hahn
• increased tumor incidence_Ptch1<tm1Hahn>/Ptch1<+>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002020I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1GtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnPtch1GtROSA26SorPtch1tm1Hahn
• increased rhabdomyosarcoma incidence_Ptch1<tm1.1Hahn>/Ptch1<+>
  http://metadb.riken.jp/0002036I129BALBcC57BL6FVBNPtch1tm11HahnPtch1Ptch1tm11HahnPtch1
• open neural tube_Ptch1<tm1.1Hahn>/Ptch1<tm1.1Hahn>
  http://metadb.riken.jp/0000929I129BALBcC57BL6FVBNPtch1tm11HahnPtch1tm11HahnPtch1tm11Hahn
• premature death_Ptch1<tm1Hahn>/Ptch1<tm1Hahn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26SorPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26Sor
• epidermal cyst_Ptch1<tm1Hahn>/Ptch1<+>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003414I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1GtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnPtch1GtROSA26SorPtch1tm1Hahn
• premature death_Ptch1<tm1Hahn>/Ptch1<+>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S1Sv129X1SvJBALBcC57BL6Ptch1tm1HahnPtch1GtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26SorGtROSA26Sortm2creERT2BrnPtch1Ptch1tm1Hahn
• premature death_Ptch1<tm1Hahn>/Ptch1<tm1Hahn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S1Sv129X1SvJBALBcC57BL6Ptch1tm1HahnPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnGtROSA26SorPtch1tm1Hahn
• premature death_Ptch1<tm1.1Hahn>/Ptch1<+>
  http://metadb.riken.jp/0002083I129BALBcC57BL6FVBNPtch1tm11HahnPtch1Ptch1tm11HahnPtch1
• embryonic lethality during organogenesis, complete penetrance_Ptch1<tm1.1Hahn>/Ptch1<tm1.1Hahn>
  http://metadb.riken.jp/0011098I129BALBcC57BL6FVBNPtch1tm11HahnPtch1tm11HahnPtch1tm11Hahn
• increased basal cell carcinoma incidence_Ptch1<tm1Hahn>/Ptch1<tm1Hahn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004208I129P2OlaHsd129S1Sv129X1SvJC57BL6Ptch1tm1HahnPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26SorPtch1tm1HahnGtROSA26Sortm2creERT2BrnGtROSA26Sor

class

http://purl.org/net/cito/citesAsAuthority

• Ptch1<tm1.1Hahn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5447563