Sotiria. Tzima, et.al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production., The Journal of experimental medicine, 2009, 206

http://rdf.ncbi.nlm.nih.gov/pubmed/19398754

Sotiria. Tzima, et.al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production., The Journal of experimental medicine, 2009, 206

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3846093
• Hmox1<tm1.1Gkl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3526228

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased inflammatory response_Hmox1<tm1.2Gkl>/Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/0001846I129BALBcJC57BL6Hmox1tm12GklHmox1tm12GklHmox1tm12Gkl
• decreased interferon-beta secretion_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008565I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• increased interferon-gamma secretion_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008566I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• increased CD4-positive, alpha beta T cell number_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008074I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• liver inflammation_Hmox1<tm1.2Gkl>/Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/0001860I129BALBcJC57BL6Hmox1tm12GklHmox1tm12GklHmox1tm12Gkl
• increased circulating tumor necrosis factor level_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008553I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• premature death_Hmox1<tm1.2Gkl>/Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/0002083I129BALBcJC57BL6Hmox1tm12GklHmox1tm12GklHmox1tm12Gkl
• decreased susceptibility to viral infection_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002410I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• postnatal lethality, incomplete penetrance_Hmox1<tm1.2Gkl>/Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/0011086I129BALBcJC57BL6Hmox1tm12GklHmox1tm12GklHmox1tm12Gkl
• increased splenocyte proliferation_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0009336I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• increased granulocyte number_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0000322I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• increased CD8-positive, alpha-beta T cell number_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008078I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• decreased susceptibility to bacterial infection induced morbidity/mortality_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0009789I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• increased B cell number_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005014I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• increased susceptibility to experimental autoimmune encephalomyelitis_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0004799I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl
• enlarged spleen_Hmox1<tm1.2Gkl>/Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/0000691I129BALBcJC57BL6Hmox1tm12GklHmox1tm12GklHmox1tm12Gkl
• increased macrophage cell number_Hmox1<tm1.1Gkl>/Hmox1<tm1.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005425I129129P2OlaHsdBALBcJC57BL6Hmox1tm11GklHmox1tm11GklLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoHmox1tm11Gkl

class

http://purl.org/net/cito/citesAsAuthority

• Hmox1<tm1.2Gkl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3846093
• Hmox1<tm1.1Gkl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3526228