Guangxun. Meng, et.al., A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses., Immunity, 2009, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/19501001

Guangxun. Meng, et.al., A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses., Immunity, 2009, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nlrp3<tm1Wstr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3850069

class

http://purl.org/net/cito/citesAsAuthority

• Nlrp3<tm1Wstr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3850069

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spleen red pulp morphology_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0002356IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• abnormal dendritic cell physiology_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0002376IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• abnormal CD4-positive, alpha beta T cell number_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008073IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased activated T cell number_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0001829IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased interleukin-17 secretion_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008681IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased interleukin-1 beta secretion_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008657IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• slow postnatal weight gain_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008489IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• reduced fertility_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0001921IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• postnatal growth retardation_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0001732IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased interleukin-18 secretion_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008684IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• dermatitis_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0001194IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased susceptibility to type IV hypersensitivity reaction_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0005617IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased leukocyte cell number_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0000218IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• enlarged liver_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0000599IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• enlarged spleen_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0000691IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• enlarged lymph nodes_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0000702IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• abnormal lymph node morphology_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0002339IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• abnormal bone marrow cell physiology_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0009278IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased T-helper 1 cell number_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008086IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• decreased survivor rate_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0008770IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• increased anti-double stranded DNA antibody level_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0004762IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• abnormal macrophage physiology_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0002451IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr
• chronic inflammation_Nlrp3<tm1Wstr>/Nlrp3<+>
  http://metadb.riken.jp/0002499IC57BL6Nlrp3tm1WstrNlrp3Nlrp3Nlrp3tm1Wstr