Youngsoo. Lee, et.al., The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1., Nature neuroscience, 2009, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/19633665

Youngsoo. Lee, et.al., The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1., Nature neuroscience, 2009, 12

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal brain interneuron morphology_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004101I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• premature death_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002083I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• ataxia_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• increased medulloblastoma incidence_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Trp53<tm1Tyj>/Trp53<+>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0006283I129S1Sv129S2SvPasC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTrp53tm1TyjTrp53TgNescre1Kln0Trp53Trp53tm1TyjXrcc1tm1PmcTgNescre1Kln
• abnormal embryonic tissue morphology_Meox2<tm1(cre)Sor>/Meox2<+>,Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>
  http://metadb.riken.jp/0002085I129S1Sv129S4SvJaeSorC57BL6Meox2tm1creSorMeox2Xrcc1tm1PmcXrcc1tm1PmcXrcc1tm1PmcMeox2tm1creSorMeox2
• premature death_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Trp53<tm1Tyj>/Trp53<+>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPasC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTrp53tm1TyjTrp53TgNescre1Kln0Trp53Trp53tm1TyjXrcc1tm1PmcTgNescre1Kln
• postnatal growth retardation_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001732I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• premature death_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPasC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTrp53tm1TyjTrp53tm1TyjTgNescre1Kln0TgNescre1KlnXrcc1tm1PmcTrp53tm1Tyj
• decreased brain size_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000774I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• increased embryonic tissue cell apoptosis_Meox2<tm1(cre)Sor>/Meox2<+>,Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>
  http://metadb.riken.jp/0013504I129S1Sv129S4SvJaeSorC57BL6Meox2tm1creSorMeox2Xrcc1tm1PmcXrcc1tm1PmcXrcc1tm1PmcMeox2tm1creSorMeox2
• increased neuron apoptosis_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003203I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• small cerebellum_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000852I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• decreased body size_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001265I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• abnormal DNA repair_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008058I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• abnormal neuron differentiation_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009937I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• decreased body weight_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001262I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• abnormal neuron differentiation_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009937I129S1Sv129S2SvPasC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTrp53tm1TyjTrp53tm1TyjTgNescre1Kln0TgNescre1KlnXrcc1tm1PmcTrp53tm1Tyj
• no abnormal phenotype detected_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>
  http://metadb.riken.jp/0002169I129S1SvC57BL6Xrcc1tm1PmcXrcc1tm1PmcXrcc1tm1Pmc
• increased medulloblastoma incidence_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0006283I129S1Sv129S2SvPasC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTrp53tm1TyjTrp53tm1TyjTgNescre1Kln0TgNescre1KlnXrcc1tm1PmcTrp53tm1Tyj
• embryonic lethality during organogenesis, complete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>
  http://metadb.riken.jp/0011098I129S1Sv129S4SvJaeSorC57BL6Meox2tm1creSorMeox2Xrcc1tm1PmcXrcc1tm1PmcXrcc1tm1PmcMeox2tm1creSorMeox2
• seizures_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002064I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• loss of GABAergic neurons_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003246I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln
• abnormal brain white matter morphology_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008026I129S1SvC57BL6SJLXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0Xrcc1tm1PmcTgNescre1Kln

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD10266
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD10266
• CD15510
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15510
• CD25562
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD25562