Lena. Wartosch, et.al., Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/19661288

Lena. Wartosch, et.al., Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, 23

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Clcn7<tm3.1Tjj>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4413670

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• loss of cortex neurons_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0003241I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• abnormal lysosome physiology_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0003172I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• accumulation of giant lysosomes in kidney/renal tubule cells_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Tg(APOE-cre)VITew/0
  http://metadb.riken.jp/0005060B6CgClcn7tm31TjjTgAPOEcreVITewClcn7tm31TjjClcn7tm31TjjTgAPOEcreVITew0TgAPOEcreVITewClcn7tm31Tjj
• astrocytosis_Clcn7<tm2Tjj>/Clcn7<tm2Tjj>
  http://metadb.riken.jp/0003354I129S1Sv129X1SvJClcn7tm2TjjClcn7tm2TjjClcn7tm2Tjj
• loss of hippocampal neurons_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0003240I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• microgliosis_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0008918I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• abnormal lysosome physiology_Clcn7<tm2Tjj>/Clcn7<tm2Tjj>
  http://metadb.riken.jp/0003172I129S1Sv129X1SvJClcn7tm2TjjClcn7tm2TjjClcn7tm2Tjj
• abnormal lysosome physiology_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Tg(APOE-cre)VITew/0
  http://metadb.riken.jp/0003172B6CgClcn7tm31TjjTgAPOEcreVITewClcn7tm31TjjClcn7tm31TjjTgAPOEcreVITew0TgAPOEcreVITewClcn7tm31Tjj
• enlarged lateral ventricles_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0008535I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• abnormal hippocampus morphology_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0000807I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• abnormal dentate gyrus morphology_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0000812I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• astrocytosis_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0003354I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• abnormal cerebral cortex morphology_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0000788I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• accumulation of giant lysosomes in kidney/renal tubule cells_Clcn7<tm2Tjj>/Clcn7<tm2Tjj>
  http://metadb.riken.jp/0005060I129S1Sv129X1SvJClcn7tm2TjjClcn7tm2TjjClcn7tm2Tjj
• abnormal autophagy_Clcn7<tm2Tjj>/Clcn7<tm2Tjj>
  http://metadb.riken.jp/0008260I129S1Sv129X1SvJClcn7tm2TjjClcn7tm2TjjClcn7tm2Tjj
• limb grasping_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0001513I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• accumulation of giant lysosomes in kidney/renal tubule cells_Clcn5<tm1Tjj>/Clcn5<+>,Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Tg(APOE-cre)VITew/0
  http://metadb.riken.jp/0005060I129Sv129S1Sv129X1SvJC57BL6C57BL6JClcn5tm1TjjClcn5Clcn7tm31TjjClcn7tm31TjjTgAPOEcreVITew0TgAPOEcreVITewClcn5tm1TjjClcn7tm31TjjClcn5
• microgliosis_Clcn7<tm2Tjj>/Clcn7<tm2Tjj>
  http://metadb.riken.jp/0008918I129S1Sv129X1SvJClcn7tm2TjjClcn7tm2TjjClcn7tm2Tjj
• neurodegeneration_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0002229I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj
• hippocampal neuron degeneration_Clcn7<tm3.1Tjj>/Clcn7<tm3.1Tjj>,Emx1<tm1.1(cre)Ito>/Emx1<+>
  http://metadb.riken.jp/0000811I129P2OlaHsd129S1Sv129X1SvJBALBcJC57BL6Clcn7tm31TjjClcn7tm31TjjEmx1tm11creItoEmx1Emx1tm11creItoEmx1Clcn7tm31Tjj

class

http://purl.org/net/cito/citesAsAuthority

• Clcn7<tm3.1Tjj>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4413670