Jana. Boy, et.al., Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3., Human molecular genetics, 2009, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/19666958

Jana. Boy, et.al., Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3., Human molecular genetics, 2009, 18

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410556

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410556

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• limb grasping_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001513I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• hyperactivity_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001399I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• Purkinje cell degeneration_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0000876I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• limb grasping_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0001513I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• decreased body weight_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001262I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• neuronal intranuclear inclusions_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0004191I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• neuronal intranuclear inclusions_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0004191I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• hyperactivity_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0001399I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• decreased anxiety-related response_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001364I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• abnormal motor capabilities/coordination/movement_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0002066I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• abnormal motor capabilities/coordination/movement_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0002066I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• Purkinje cell degeneration_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0000876I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• decreased body weight_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001262I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• thin cerebellar molecular layer_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0000890I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• abnormal Purkinje cell morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0000877I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• abnormal motor learning_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0002804I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• impaired coordination_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001405I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• decreased anxiety-related response_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0001364I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• abnormal gait_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001406I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• decreased anxiety-related response_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001364I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• impaired coordination_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0001405I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• limb grasping_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001513I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• impaired coordination_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001405I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• abnormal motor capabilities/coordination/movement_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0002066I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904OlriTgtetOATXN32904OlriTgPrnptTAF959SbpPrnptm1CweTgtetOATXN32904Olri
• hyperactivity_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
  http://metadb.riken.jp/0001399I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959Sbp0TgtetOATXN32904OlriTgtetOATXN32904OlriTgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp
• neuronal intranuclear inclusions_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
  http://metadb.riken.jp/0004191I129S7SvEvBrdC57BL6FVBPrnptm1CwePrnptm1CweTgPrnptTAF959SbpTgPrnptTAF959SbpTgtetOATXN32904Olri0TgtetOATXN32904OlriPrnptm1CweTgPrnptTAF959Sbp