Xudong. Zhao, et.al., The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain., Developmental cell, 2009, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/19686682

Xudong. Zhao, et.al., The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain., Developmental cell, 2009, 17

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal dentate gyrus morphology_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0000812I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• abnormal neuronal precursor proliferation_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0004948I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• abnormal stratification in cerebral cortex_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0000790I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• abnormal brain morphology_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0002152I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• thin cerebral cortex_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0006254I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• abnormal cerebral cortex morphology_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0000788I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• neonatal lethality_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0002058I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• decreased brain size_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0000774I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• increased neuronal precursor cell number_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0004980I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag
• small cerebellum_Huwe1<tm1Alas>/Y,Tg(Nes-cre)1Kag/0
  http://metadb.riken.jp/0000852I129S7SvEvBrdHuwe1tm1AlasYTgNescre1Kag0Huwe1tm1AlasTgNescre1Kag

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD12269
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12269