Madeline A. Lancaster, et.al., Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy., Nature medicine, 2009, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/19718039

Madeline A. Lancaster, et.al., Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy., Nature medicine, 2009, 15

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ahi1<tm1Jgg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4367773

class

http://purl.org/net/cito/citesAsAuthority

• Ahi1<tm1Jgg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4367773

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• dilated renal tubules_Ahi1<tm1Jgg>/Ahi1<+>,Lrp6<Gt(Ex187)Byg>/Lrp6<+>
  http://metadb.riken.jp/0002705I129P2OlaHsd129S1Sv129X1SvJAhi1tm1JggAhi1Lrp6GtEx187BygLrp6Lrp6Ahi1tm1JggAhi1Lrp6GtEx187Byg
• isosthenuria_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0013305I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• abnormal kidney physiology_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0002136I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• abnormal response to injury_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0005164I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• small kidney_Ahi1<tm1Jgg>/Ahi1<+>,Lrp6<Gt(Ex187)Byg>/Lrp6<+>
  http://metadb.riken.jp/0002989I129P2OlaHsd129S1Sv129X1SvJAhi1tm1JggAhi1Lrp6GtEx187BygLrp6Lrp6Ahi1tm1JggAhi1Lrp6GtEx187Byg
• increased circulating creatinine level_Ahi1<tm1Jgg>/Ahi1<+>,Lrp6<Gt(Ex187)Byg>/Lrp6<+>
  http://metadb.riken.jp/0005553I129P2OlaHsd129S1Sv129X1SvJAhi1tm1JggAhi1Lrp6GtEx187BygLrp6Lrp6Ahi1tm1JggAhi1Lrp6GtEx187Byg
• renal fibrosis_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0003985I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• abnormal renal tubule morphology_Ahi1<tm1Jgg>/Ahi1<+>,Lrp6<Gt(Ex187)Byg>/Lrp6<+>
  http://metadb.riken.jp/0002703I129P2OlaHsd129S1Sv129X1SvJAhi1tm1JggAhi1Lrp6GtEx187BygLrp6Lrp6Ahi1tm1JggAhi1Lrp6GtEx187Byg
• premature death_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• dilated renal tubules_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0002705I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• kidney cysts_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0003675I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• kidney cysts_Ahi1<tm1Jgg>/Ahi1<+>,Lrp6<Gt(Ex187)Byg>/Lrp6<+>
  http://metadb.riken.jp/0003675I129P2OlaHsd129S1Sv129X1SvJAhi1tm1JggAhi1Lrp6GtEx187BygLrp6Lrp6Ahi1tm1JggAhi1Lrp6GtEx187Byg
• decreased circulating serum albumin level_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0005419I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• small kidney_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0002989I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• kidney inflammation_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0001859I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• abnormal kidney morphology_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0002135I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• abnormal basement membrane morphology_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0004272I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• decreased body size_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg
• increased circulating creatinine level_Ahi1<tm1Jgg>/Ahi1<tm1Jgg>,Tg(TCF/Lef1-lacZ)34Efu/0
  http://metadb.riken.jp/0005553I129S1Sv129X1SvJAhi1tm1JggAhi1tm1JggTgTCFLef1lacZ34Efu0TgTCFLef1lacZ34EfuAhi1tm1Jgg