Tomokazu. Matsuda, et.al., Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/19955657

Tomokazu. Matsuda, et.al., Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice., The Journal of clinical investigation, 2010, 120

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cebpb<tm1.1Maka>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4421439
• Tg(Ins2-Cebpb)2Maka
  http://metadb.riken.jp/db/mgi_rdf/MGI:4421493

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreas physiology_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0002693BKSCgDock7mLeprdbJclLeprdbLeprdbLeprdb
• decreased pancreatic beta cell mass_Tg(Ins2-Cebpb)2Maka/0
  http://metadb.riken.jp/0009114IC57BL6TgIns2Cebpb2Maka0TgIns2Cebpb2Maka
• hyperglycemia_Ins2<Akita>/Ins2<Akita>
  http://metadb.riken.jp/0001559IC57BL6NSlcIns2AkitaIns2AkitaIns2Akita
• increased pancreatic beta cell mass_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Lepr<db>/Lepr<db>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009113I129P2OlaHsdC57BL6JC57BLKSJCBAJCebpbtm11MakaCebpbtm11MakaLeprdbLeprdbTgIns2cre23Herr0Cebpbtm11MakaTgIns2cre23HerrLeprdb
• abnormal pancreas physiology_Tg(Ins2-Cebpb)2Maka/0
  http://metadb.riken.jp/0002693IC57BL6TgIns2Cebpb2Maka0TgIns2Cebpb2Maka
• increased circulating insulin level_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Lepr<db>/Lepr<db>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002079I129P2OlaHsdC57BL6JC57BLKSJCBAJCebpbtm11MakaCebpbtm11MakaLeprdbLeprdbTgIns2cre23Herr0Cebpbtm11MakaTgIns2cre23HerrLeprdb
• decreased insulin secretion_Tg(Ins2-Cebpb)2Maka/0
  http://metadb.riken.jp/0003059IC57BL6TgIns2Cebpb2Maka0TgIns2Cebpb2Maka
• abnormal pancreatic beta cell mass_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Ins2<Akita>/Ins2<Akita>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009112I129P2OlaHsdC57BL6JC57BL6NSlcCBAJCebpbtm11MakaCebpbtm11MakaIns2AkitaIns2AkitaTgIns2cre23Herr0TgIns2cre23HerrCebpbtm11MakaIns2Akita
• decreased circulating insulin level_Ins2<Akita>/Ins2<Akita>
  http://metadb.riken.jp/0002727IC57BL6NSlcIns2AkitaIns2AkitaIns2Akita
• increased circulating glucose level_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Ins2<Akita>/Ins2<Akita>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005559I129P2OlaHsdC57BL6JC57BL6NSlcCBAJCebpbtm11MakaCebpbtm11MakaIns2AkitaIns2AkitaTgIns2cre23Herr0TgIns2cre23HerrCebpbtm11MakaIns2Akita
• decreased circulating insulin level_Tg(Ins2-Cebpb)2Maka/0
  http://metadb.riken.jp/0002727IC57BL6TgIns2Cebpb2Maka0TgIns2Cebpb2Maka
• increased insulin secretion_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003058I129P2OlaHsdC57BL6JCBAJCebpbtm11MakaCebpbtm11MakaTgIns2cre23Herr0Cebpbtm11MakaTgIns2cre23Herr
• increased circulating insulin level_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0002079BKSCgDock7mLeprdbJclLeprdbLeprdbLeprdb
• increased pancreatic beta cell mass_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0009113BKSCgDock7mLeprdbJclLeprdbLeprdbLeprdb
• hyperglycemia_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0001559BKSCgDock7mLeprdbJclLeprdbLeprdbLeprdb
• increased pancreatic islet cell apoptosis_Ins2<Akita>/Ins2<Akita>
  http://metadb.riken.jp/0014121IC57BL6NSlcIns2AkitaIns2AkitaIns2Akita
• increased circulating glucose level_Tg(Ins2-Cebpb)2Maka/0
  http://metadb.riken.jp/0005559IC57BL6TgIns2Cebpb2Maka0TgIns2Cebpb2Maka
• decreased insulin secretion_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Ins2<Akita>/Ins2<Akita>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003059I129P2OlaHsdC57BL6JC57BL6NSlcCBAJCebpbtm11MakaCebpbtm11MakaIns2AkitaIns2AkitaTgIns2cre23Herr0TgIns2cre23HerrCebpbtm11MakaIns2Akita
• abnormal pancreatic islet cell apoptosis_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Lepr<db>/Lepr<db>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009488I129P2OlaHsdC57BL6JC57BLKSJCBAJCebpbtm11MakaCebpbtm11MakaLeprdbLeprdbTgIns2cre23Herr0Cebpbtm11MakaTgIns2cre23HerrLeprdb
• abnormal pancreatic islet cell apoptosis_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Ins2<Akita>/Ins2<Akita>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009488I129P2OlaHsdC57BL6JC57BL6NSlcCBAJCebpbtm11MakaCebpbtm11MakaIns2AkitaIns2AkitaTgIns2cre23Herr0TgIns2cre23HerrCebpbtm11MakaIns2Akita
• decreased circulating insulin level_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Ins2<Akita>/Ins2<Akita>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002727I129P2OlaHsdC57BL6JC57BL6NSlcCBAJCebpbtm11MakaCebpbtm11MakaIns2AkitaIns2AkitaTgIns2cre23Herr0TgIns2cre23HerrCebpbtm11MakaIns2Akita
• increased pancreatic islet cell apoptosis_Tg(Ins2-Cebpb)2Maka/0
  http://metadb.riken.jp/0014121IC57BL6TgIns2Cebpb2Maka0TgIns2Cebpb2Maka
• hyperglycemia_Cebpb<tm1.1Maka>/Cebpb<tm1.1Maka>,Lepr<db>/Lepr<db>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001559I129P2OlaHsdC57BL6JC57BLKSJCBAJCebpbtm11MakaCebpbtm11MakaLeprdbLeprdbTgIns2cre23Herr0Cebpbtm11MakaTgIns2cre23HerrLeprdb
• increased pancreatic islet cell apoptosis_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0014121BKSCgDock7mLeprdbJclLeprdbLeprdbLeprdb
• decreased pancreatic beta cell mass_Ins2<Akita>/Ins2<Akita>
  http://metadb.riken.jp/0009114IC57BL6NSlcIns2AkitaIns2AkitaIns2Akita
• decreased insulin secretion_Ins2<Akita>/Ins2<Akita>
  http://metadb.riken.jp/0003059IC57BL6NSlcIns2AkitaIns2AkitaIns2Akita
• abnormal pancreas physiology_Ins2<Akita>/Ins2<Akita>
  http://metadb.riken.jp/0002693IC57BL6NSlcIns2AkitaIns2AkitaIns2Akita

class

http://purl.org/net/cito/citesAsAuthority

• Cebpb<tm1.1Maka>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4421439
• Tg(Ins2-Cebpb)2Maka
  http://metadb.riken.jp/db/mgi_rdf/MGI:4421493

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased pancreatic islet cell apoptosis in RBRC02661
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012396
• abnormal pancreas physiology in RBRC02661
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1011700
• abnormal pancreas physiology in RBRC02659
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014242
• abnormal pancreatic islet cell apoptosis in RBRC02661
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1011720
• decreased pancreatic beta cell mass in RBRC02659
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014264
• decreased pancreatic beta cell mass in RBRC02661
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1011717
• abnormal pancreatic islet cell apoptosis in RBRC02659
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014267