Adriano. Flora, et.al., Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma., Science (New York, N.Y.), 2009, 326

http://rdf.ncbi.nlm.nih.gov/pubmed/19965762

Adriano. Flora, et.al., Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma., Science (New York, N.Y.), 2009, 326

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Atoh1<tm6.1Hzo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4420925

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cerebellum external granule cell layer morphology_Atoh1<tm3Hzo>/Atoh1<+>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0000872I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1GtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcAtoh1GtROSA26Sortm1creERTNat
• abnormal neuronal precursor proliferation_Atoh1<tm3Hzo>/Atoh1<tm1Hzo>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0004948I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1tm1HzoGtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcGtROSA26Sortm1creERTNatAtoh1tm1Hzo
• abnormal cerebellum morphology_Atoh1<tm3Hzo>/Atoh1<+>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0000849I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1GtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcAtoh1GtROSA26Sortm1creERTNat
• thin external granule cell layer_Atoh1<tm3Hzo>/Atoh1<tm1Hzo>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000873I129129S7SvEvBrdAtoh1tm3HzoAtoh1tm1HzoGtROSA26Sortm1creERTNatGtROSA26SorAtoh1tm1HzoGtROSA26SorGtROSA26Sortm1creERTNatAtoh1tm3Hzo
• no abnormal phenotype detected_Atoh1<tm6.1Hzo>/Atoh1<tm6.1Hzo>
  http://metadb.riken.jp/0002169I129S7SvEvBrdC57BL6SJLAtoh1tm61HzoAtoh1tm61HzoAtoh1tm61Hzo
• cerebellum atrophy_Atoh1<tm3Hzo>/Atoh1<tm1Hzo>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0014185I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1tm1HzoGtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcGtROSA26Sortm1creERTNatAtoh1tm1Hzo
• thin external granule cell layer_Atoh1<tm3Hzo>/Atoh1<tm1Hzo>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0000873I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1tm1HzoGtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcGtROSA26Sortm1creERTNatAtoh1tm1Hzo
• decreased neuronal precursor proliferation_Atoh1<tm3Hzo>/Atoh1<tm3Hzo>
  http://metadb.riken.jp/0020394I129S7SvEvBrdAtoh1tm3HzoAtoh1tm3HzoAtoh1tm3Hzo
• abnormal neuronal precursor proliferation_Atoh1<tm3Hzo>/Atoh1<+>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0004948I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1GtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcAtoh1GtROSA26Sortm1creERTNat
• irregular external granule cell layer_Atoh1<tm3Hzo>/Atoh1<+>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>
  http://metadb.riken.jp/0000874I129129S7SvEvBrd129X1SvJAtoh1tm3HzoAtoh1GtROSA26Sortm1creERTNatGtROSA26Sortm1SmoEYFPAmcAtoh1tm3HzoGtROSA26Sortm1SmoEYFPAmcAtoh1GtROSA26Sortm1creERTNat

class

http://purl.org/net/cito/citesAsAuthority

• Atoh1<tm6.1Hzo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4420925