Sayoko. Fujimura, et.al., Notch2 activation in the embryonic kidney depletes nephron progenitors., Journal of the American Society of Nephrology : JASN, 2010, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/20299358

Sayoko. Fujimura, et.al., Notch2 activation in the embryonic kidney depletes nephron progenitors., Journal of the American Society of Nephrology : JASN, 2010, 21

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Notch2)Ryn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5430391

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Notch2)Ryn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5430391

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• dilated proximal convoluted tubules_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0009050I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• small kidney_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0002989I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• impaired branching involved in ureteric bud morphogenesis_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0004936I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal renal tubule morphology_Gt(ROSA)26Sor<tm1(Notch1)Dam>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0002703I129S4SvJaeSorC57BL6JGtROSA26Sortm1Notch1DamGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26SorGtROSA26Sortm1Notch1DamSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal metanephric ureteric bud development_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011457I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal kidney development_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0000527I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• dilated renal tubules_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0002705I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• absent metanephric mesenchyme_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011387I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• neonatal lethality, complete penetrance_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011087I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• renal glomerulus cysts_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011682I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2
• abnormal nephrogenic zone morphology_Gt(ROSA)26Sor<tm2(Notch2)Ryn>/Gt(ROSA)26Sor<+>,Six2<tm1(tTA,tetO-EGFP/cre)Amc>/Six2<+>
  http://metadb.riken.jp/0011334I129Sv129P2OlaHsdC57BL6JGtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2GtROSA26Sortm2Notch2RynGtROSA26SorSix2tm1tTAtetOEGFPcreAmcSix2