Vijay A K. Rathinam, et.al., The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses., Nature immunology, 2010, 11

http://rdf.ncbi.nlm.nih.gov/pubmed/20351692

Vijay A K. Rathinam, et.al., The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses., Nature immunology, 2010, 11

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased susceptibility to viral infection_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0002418I129S5SvEvBrdC57BL6Pycardtm1FlvPycardtm1FlvPycardtm1Flv
• decreased interferon-beta secretion_Irf3<tm1Ttg>/Irf3<tm1Ttg>,Irf7<tm1Ttg>/Irf7<tm1Ttg>
  http://metadb.riken.jp/0008565I129P2OlaHsd129SSvEvIrf3tm1TtgIrf3tm1TtgIrf7tm1TtgIrf7tm1TtgIrf3tm1TtgIrf7tm1Ttg
• increased susceptibility to viral infection_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0002418I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• increased susceptibility to viral infection_Irf3<tm1Ttg>/Irf3<tm1Ttg>,Irf7<tm1Ttg>/Irf7<tm1Ttg>
  http://metadb.riken.jp/0002418I129P2OlaHsd129SSvEvIrf3tm1TtgIrf3tm1TtgIrf7tm1TtgIrf7tm1TtgIrf3tm1TtgIrf7tm1Ttg
• decreased circulating interleukin-18 level_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0008636I129S5SvEvBrdC57BL6Pycardtm1FlvPycardtm1FlvPycardtm1Flv
• decreased circulating interleukin-18 level_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0008636I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• decreased interleukin-18 secretion_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0008685I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• increased interferon-beta secretion_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0008564I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• increased susceptibility to bacterial infection_Irf3<tm1Ttg>/Irf3<tm1Ttg>,Irf7<tm1Ttg>/Irf7<tm1Ttg>
  http://metadb.riken.jp/0002412I129P2OlaHsd129SSvEvIrf3tm1TtgIrf3tm1TtgIrf7tm1TtgIrf7tm1TtgIrf3tm1TtgIrf7tm1Ttg
• decreased interleukin-1 beta secretion_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0008658I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• decreased NK cell number_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0008045I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• decreased interleukin-1 beta secretion_Irf3<tm1Ttg>/Irf3<tm1Ttg>,Irf7<tm1Ttg>/Irf7<tm1Ttg>
  http://metadb.riken.jp/0008658I129P2OlaHsd129SSvEvIrf3tm1TtgIrf3tm1TtgIrf7tm1TtgIrf7tm1TtgIrf3tm1TtgIrf7tm1Ttg
• decreased NK cell number_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0008045I129S5SvEvBrdC57BL6Pycardtm1FlvPycardtm1FlvPycardtm1Flv
• abnormal macrophage physiology_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0002451I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg
• increased susceptibility to bacterial infection_Aim2<Gt(CSG445)Byg>/Aim2<Gt(CSG445)Byg>
  http://metadb.riken.jp/0002412I129P2OlaHsdC57BL6Aim2GtCSG445BygAim2GtCSG445BygAim2GtCSG445Byg