Juan. Li, et.al., JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia., Blood, 2010, 116

http://rdf.ncbi.nlm.nih.gov/pubmed/20489053

Juan. Li, et.al., JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia., Blood, 2010, 116

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Jak2<tm1(JAK2)Argr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836590

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased leukocyte cell number_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000221I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• abnormal bone marrow morphology_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002397I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• thrombocytosis_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005505I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• abnormal hematopoietic system physiology_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001545I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• decreased hematopoietic stem cell number_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• abnormal erythropoiesis_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000245I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• anemia_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• increased erythroid progenitor cell number_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003135I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• enlarged spleen_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• abnormal bone marrow cell morphology/development_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002398I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• increased hematocrit_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002608I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• abnormal common myeloid progenitor cell morphology_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006410I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• abnormal megakaryocyte differentiation_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000229I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• increased leukocyte cell number_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• increased hemoglobin content_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005564I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• increased erythrocyte cell number_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003131I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr
• increased megakaryocyte cell number_Jak2<tm1(JAK2)Argr>/Jak2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008254I129S7SvEvBrdC57BL6CBAJak2tm1JAK2ArgrJak2TgMx1cre1Cgn0Jak2TgMx1cre1CgnJak2tm1JAK2Argr

class

http://purl.org/net/cito/citesAsAuthority

• Jak2<tm1(JAK2)Argr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836590