Roza I. Nurieva, et.al., The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation., Immunity, 2010, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/20493730

Roza I. Nurieva, et.al., The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation., Immunity, 2010, 32

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Rnf128<tm1Cdon>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4459531

class

http://purl.org/net/cito/citesAsAuthority

• Rnf128<tm1Cdon>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4459531

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased interferon-gamma secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008566I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• CNS inflammation_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0006082I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased T cell proliferation_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0005348IC57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• abnormal immune tolerance_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0005000I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• decreased interleukin-5 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008703I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased interleukin-17 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008681IC57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased interferon-gamma secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008566IC57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased splenocyte proliferation_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0009336I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased susceptibility to experimental autoimmune encephalomyelitis_Rnf128<tm1Cdon>/Rnf128<+>
  http://metadb.riken.jp/0004799I129C57BL6Rnf128tm1CdonRnf128Rnf128tm1CdonRnf128
• increased interleukin-21 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0009057I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• enlarged mesenteric lymph nodes_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008466I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• enlarged spleen_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0000691I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased anti-double stranded DNA antibody level_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0004762IC57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased IgM level_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0002494I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• abnormal regulatory T cell physiology_Foxp3<tm2Ayr>/Foxp3<+>,Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0004946I129S1Sv129X1SvJC57BL6Foxp3tm2AyrFoxp3Rnf128tm1CdonRnf128tm1CdonFoxp3Foxp3tm2AyrRnf128tm1Cdon
• increased interferon-gamma secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0008566I129BALBcC57BL6Rnf128tm1CdonRnf128tm1CdonTgTcraTcrb425Cbn0TgTcraTcrb425CbnRnf128tm1Cdon
• abnormal immune tolerance_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0005000I129BALBcC57BL6Rnf128tm1CdonRnf128tm1CdonTgTcraTcrb425Cbn0TgTcraTcrb425CbnRnf128tm1Cdon
• increased interleukin-2 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008687IC57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• lung inflammation_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0001861I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• decreased interleukin-13 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008673I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased interleukin-4 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008699I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased IgG1 level_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008499I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• decreased interleukin-4 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008700I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• abnormal interleukin secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008568I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased interleukin-2 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008687I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased anti-double stranded DNA antibody level_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0004762I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• abnormal regulatory T cell physiology_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0004946I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased splenocyte proliferation_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0009336I129BALBcC57BL6Rnf128tm1CdonRnf128tm1CdonTgTcraTcrb425Cbn0TgTcraTcrb425CbnRnf128tm1Cdon
• increased interleukin-2 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0008687I129BALBcC57BL6Rnf128tm1CdonRnf128tm1CdonTgTcraTcrb425Cbn0TgTcraTcrb425CbnRnf128tm1Cdon
• increased interleukin-17 secretion_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0008681I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon
• increased susceptibility to experimental autoimmune encephalomyelitis_Rnf128<tm1Cdon>/Rnf128<tm1Cdon>
  http://metadb.riken.jp/0004799I129C57BL6Rnf128tm1CdonRnf128tm1CdonRnf128tm1Cdon

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD28676
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28676
• CD01658
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD01658