Yun. Lu, et.al., Evidence that SOX2 overexpression is oncogenic in the lung., PloS one, 2010, 5

http://rdf.ncbi.nlm.nih.gov/pubmed/20548776

Yun. Lu, et.al., Evidence that SOX2 overexpression is oncogenic in the lung., PloS one, 2010, 5

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4820800
• Gt(ROSA)26Sor<tm2(CAG-EGFP)Blh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4820801

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4820800
• Gt(ROSA)26Sor<tm2(CAG-EGFP)Blh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4820801

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased lung adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0002027I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh
• lung epithelium hyperplasia_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0010945I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh
• respiratory distress_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0001954I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh
• premature death_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0002083I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh
• bronchiolar epithelial hyperplasia_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0010910I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh
• bronchial epithelial hyperplasia_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>,Scgb1a1<tm1(cre/ERT)Blh>/Scgb1a1<+>
  http://metadb.riken.jp/0005488I129S6SvEvC57BL6GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26Sortm1CAGSox2EGFPBlhScgb1a1tm1creERTBlhScgb1a1Scgb1a1Scgb1a1tm1creERTBlhGtROSA26Sortm1CAGSox2EGFPBlh
• abnormal lung morphology_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0001175I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh
• increased lung adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>,Scgb1a1<tm1(cre/ERT)Blh>/Scgb1a1<+>
  http://metadb.riken.jp/0002027I129S6SvEvC57BL6GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26Sortm1CAGSox2EGFPBlhScgb1a1tm1creERTBlhScgb1a1Scgb1a1Scgb1a1tm1creERTBlhGtROSA26Sortm1CAGSox2EGFPBlh
• bronchial epithelial hyperplasia_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Scgb1a1<tm1(cre/ERT)Blh>/Scgb1a1<+>
  http://metadb.riken.jp/0005488I129S6SvEvC57BL6GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorScgb1a1tm1creERTBlhScgb1a1Scgb1a1tm1creERTBlhScgb1a1GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlh
• bronchial epithelial hyperplasia_Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh>/Gt(ROSA)26Sor<+>,Tg(Sftpc-cre)1Blh/0
  http://metadb.riken.jp/0005488I129SSvEvC57BL6DBA2GtROSA26Sortm1CAGSox2EGFPBlhGtROSA26SorTgSftpccre1Blh0GtROSA26SorGtROSA26Sortm1CAGSox2EGFPBlhTgSftpccre1Blh