Biliana. Marcheva, et.al., Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes., Nature, 2010, 466

http://rdf.ncbi.nlm.nih.gov/pubmed/20562852

Biliana. Marcheva, et.al., Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes., Nature, 2010, 466

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased pancreatic islet cell apoptosis_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0014121IC57BL6JClockm1JtClockm1JtClockm1Jt
• hyperglycemia_Arntl<tm2Bra>/Arntl<tm2Bra>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0001559I129C57BL6C57BL6JCBAICRArntltm2BraArntltm2BraTgPdx1cre891Dam0Arntltm2BraTgPdx1cre891Dam
• abnormal pancreatic beta cell physiology_Arntl<tm2Bra>/Arntl<tm2Bra>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003562I129C57BL6C57BL6JCBAICRArntltm2BraArntltm2BraTgPdx1cre891Dam0Arntltm2BraTgPdx1cre891Dam
• abnormal pancreatic islet morphology_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0005215IC57BL6JClockm1JtClockm1JtClockm1Jt
• increased insulin sensitivity_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0002891IC57BL6JClockm1JtClockm1JtClockm1Jt
• decreased pancreatic islet number_Arntl<tm1Bra>/Arntl<tm1Bra>
  http://metadb.riken.jp/0009168I129SvC57BL6Arntltm1BraArntltm1BraArntltm1Bra
• decreased insulin secretion_Arntl<tm2Bra>/Arntl<tm2Bra>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003059I129C57BL6C57BL6JCBAICRArntltm2BraArntltm2BraTgPdx1cre891Dam0Arntltm2BraTgPdx1cre891Dam
• small pancreatic islets_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0009172IC57BL6JClockm1JtClockm1JtClockm1Jt
• impaired glucose tolerance_Arntl<tm2Bra>/Arntl<tm2Bra>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005293I129C57BL6C57BL6JCBAICRArntltm2BraArntltm2BraTgPdx1cre891Dam0Arntltm2BraTgPdx1cre891Dam
• abnormal circadian rhythm_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0001502IC57BL6JClockm1JtClockm1JtClockm1Jt
• hyperglycemia_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0001559IC57BL6JClockm1JtClockm1JtClockm1Jt
• decreased insulin secretion_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0003059IC57BL6JClockm1JtClockm1JtClockm1Jt
• insulin resistance_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0005331IC57BL6JClockm1JtClockm1JtClockm1Jt
• abnormal pancreas physiology_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0002693IC57BL6JClockm1JtClockm1JtClockm1Jt
• decreased insulin secretion_Arntl<tm1Bra>/Arntl<tm1Bra>
  http://metadb.riken.jp/0003059I129SvC57BL6Arntltm1BraArntltm1BraArntltm1Bra
• impaired glucose tolerance_Clock<m1Jt>/Clock<m1Jt>
  http://metadb.riken.jp/0005293IC57BL6JClockm1JtClockm1JtClockm1Jt