Michael G. Kharas, et.al., Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia., Nature medicine, 2010, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/20616797

Michael G. Kharas, et.al., Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia., Nature medicine, 2010, 16

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm6(tetO-MSI2)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4822360

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased bone marrow cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000321I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• abnormal erythrocyte morphology_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002447I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased liver weight_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002981I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• enlarged spleen_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000691I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• decreased lymphocyte cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005016I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• spleen hyperplasia_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000693I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• thrombocytopenia_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003179I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• abnormal leukocyte morphology_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008246I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased leukocyte cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000218I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased erythrocyte cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003131I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• decreased common myeloid progenitor cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008813I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• decreased neutrophil cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000222I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased leukemia incidence_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002026I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased mean corpuscular volume_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002590I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased spleen weight_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004952I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• abnormal myelopoiesis_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001601I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased hematopoietic stem cell number_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004809I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased sensitivity to induced morbidity/mortality_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009763I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• abnormal bone marrow cell morphology/development_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002398I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae
• increased hematocrit_Col1a1<tm6(tetO-MSI2)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002608I129S4SvJaeC57BL6Col1a1tm6tetOMSI2JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm6tetOMSI2Jae

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm6(tetO-MSI2)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4822360

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00087
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00087