Blake. Ferguson, et.al., Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis., Pigment cell & melanoma research, 2010, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/20718941

Blake. Ferguson, et.al., Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis., Pigment cell & melanoma research, 2010, 23

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cutaneous melanoma incidence_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0010322FVBCgTrp53tm1BrnTgTyrcreERT213BosTgTyrNRASQ61K1BeeTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0TgTyrNRASQ61K1Bee0TgTyrcreERT213BosTrp53tm1BrnTgTyrNRASQ61K1Bee
• increased cutaneous melanoma incidence_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0010322FVBCgCdk4tm11BbdTgTyrNRASQ61K1BeeCdk4tm11BbdCdk4tm11BbdTgTyrNRASQ61K1Bee0TgTyrNRASQ61K1BeeCdk4tm11Bbd
• skin lesions_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0001212FVBCgCdk4tm11BbdTgTyrNRASQ61K1BeeCdk4tm11BbdCdk4tm11BbdTgTyrNRASQ61K1Bee0TgTyrNRASQ61K1BeeCdk4tm11Bbd
• increased melanocyte number_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0012022FVBCgCdk4tm11BbdTgTyrNRASQ61K1BeeCdk4tm11BbdCdk4tm11BbdTgTyrNRASQ61K1Bee0TgTyrNRASQ61K1BeeCdk4tm11Bbd
• abnormal melanocyte proliferation_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0010741FVBCgCdk4tm11BbdTgTyrNRASQ61K1BeeCdk4tm11BbdCdk4tm11BbdTgTyrNRASQ61K1Bee0TgTyrNRASQ61K1BeeCdk4tm11Bbd
• increased incidence of tumors by UV-induction_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Tyr-cre/ERT2)13Bos/0,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0004501FVBCgTrp53tm1BrnTgTyrcreERT213BosTgTyrNRASQ61K1BeeTrp53tm1BrnTrp53tm1BrnTgTyrcreERT213Bos0TgTyrNRASQ61K1Bee0TgTyrcreERT213BosTrp53tm1BrnTgTyrNRASQ61K1Bee
• increased incidence of tumors by UV-induction_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>,Tg(Tyr-NRAS*Q61K)1Bee/0
  http://metadb.riken.jp/0004501FVBCgCdk4tm11BbdTgTyrNRASQ61K1BeeCdk4tm11BbdCdk4tm11BbdTgTyrNRASQ61K1Bee0TgTyrNRASQ61K1BeeCdk4tm11Bbd