Sean M. Post, et.al., A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development., Cancer cell, 2010, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/20832750

Sean M. Post, et.al., A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development., Cancer cell, 2010, 18

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mdm2<tm4.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835495
• Mdm2<tm3.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835494

class

http://purl.org/net/cito/citesAsAuthority

• Mdm2<tm4.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835495
• Mdm2<tm3.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835494

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased histiocytic sarcoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0009321B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased lymphoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0012431B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased hemangiosarcoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0003667B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased sarcoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002032B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased sarcoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002032B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased lymphoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>
  http://metadb.riken.jp/0012431B6129S6Mdm2tm31GloMdm2tm31GloMdm2tm31GloMdm2tm31Glo
• decreased cellular sensitivity to ionizing radiation_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>
  http://metadb.riken.jp/0004228B6129S6Mdm2tm31GloMdm2tm31GloMdm2tm31GloMdm2tm31Glo
• increased lung adenoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002048B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• premature death_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>
  http://metadb.riken.jp/0002083B6129S6Mdm2tm31GloMdm2tm31GloMdm2tm31GloMdm2tm31Glo
• increased lipoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0010343B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased adenocarcinoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0009308B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased liver adenoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0003324B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased fibroblast proliferation_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>
  http://metadb.riken.jp/0011703B6129S6Mdm2tm31GloMdm2tm31GloMdm2tm31GloMdm2tm31Glo
• increased osteosarcoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0003789B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased mammary adenocarcinoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>
  http://metadb.riken.jp/0001883B6129S6Mdm2tm31GloMdm2tm31GloMdm2tm31GloMdm2tm31Glo
• increased leiomyosarcoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002035B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased tumor incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002020B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• premature death_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002083B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased liver adenocarcinoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0009591B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased fibrosarcoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0010363B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased fibrosarcoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0010363B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased carcinoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002038B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased osteosarcoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0003789B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased tumor incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>
  http://metadb.riken.jp/0002020B6129S6Mdm2tm31GloMdm2tm31GloMdm2tm31GloMdm2tm31Glo
• decreased cellular sensitivity to ionizing radiation_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0004228B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased mammary adenocarcinoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0001883B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased liver adenocarcinoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0009591B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased lymphoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0012431B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased squamous cell carcinoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0004207B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased carcinoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002038B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased papilloma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002014B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased histiocytic sarcoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0009321B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo
• increased squamous cell carcinoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0004207B6129SMdm2tm41GloTrp53tm31GloMdm2tm41GloMdm2tm41GloTrp53tm31GloTrp53Mdm2tm41GloTrp53Trp53tm31Glo
• increased sarcoma incidence_Mdm2<tm4.1Glo>/Mdm2<tm4.1Glo>
  http://metadb.riken.jp/0002032B6129S6Mdm2tm41GloMdm2tm41GloMdm2tm41GloMdm2tm41Glo
• increased adenocarcinoma incidence_Mdm2<tm3.1Glo>/Mdm2<tm3.1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0009308B6129SMdm2tm31GloTrp53tm31GloMdm2tm31GloMdm2tm31GloTrp53tm31GloTrp53Trp53Trp53tm31GloMdm2tm31Glo