Daisuke. Nakada, et.al., Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells., Nature, 2010, 468

http://rdf.ncbi.nlm.nih.gov/pubmed/21124450

Daisuke. Nakada, et.al., Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells., Nature, 2010, 468

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Stk11<tm1.1Sjm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4440829
• Prkaa1<tm1.1Sjm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836199
• Prkaa2<tm1.1Sjm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836201

class

http://purl.org/net/cito/citesAsAuthority

• Stk11<tm1.1Sjm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4440829
• Prkaa1<tm1.1Sjm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836199
• Prkaa2<tm1.1Sjm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836201

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal mitotic spindle morphology_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009760IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• abnormal bone marrow cell physiology_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009278IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• decreased bone marrow cell number_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• abnormal bone marrow cell physiology_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0009278I129SSvEvC57BL6SJLStk11tm11SjmStk11tm11SjmTgUBCcreERT21Ejb0Stk11tm11SjmTgUBCcreERT21Ejb
• increased mitochondrial fission_Prkaa1<tm1.1Sjm>/Prkaa1<tm1.1Sjm>,Prkaa2<tm1.1Sjm>/Prkaa2<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006038IC57BL6CBASJLPrkaa1tm11SjmPrkaa1tm11SjmPrkaa2tm11SjmPrkaa2tm11SjmTgMx1cre1Cgn0Prkaa1tm11SjmPrkaa2tm11SjmTgMx1cre1Cgn
• pancytopenia_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005152IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• decreased leukocyte cell number_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000221IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• thrombocytopenia_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003179IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• aneuploidy_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004024IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• decreased hematopoietic stem cell number_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• abnormal bone marrow cell morphology/development_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002398IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• increased mitochondrial fission_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006038IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• increased hematopoietic stem cell number_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• thymus hypoplasia_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001823IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• decreased erythrocyte cell number_Stk11<tm1.1Sjm>/Stk11<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875IC57BL6CBASJLStk11tm11SjmStk11tm11SjmTgMx1cre1Cgn0TgMx1cre1CgnStk11tm11Sjm
• decreased hematopoietic stem cell number_Prkaa1<tm1.1Sjm>/Prkaa1<tm1.1Sjm>,Prkaa2<tm1.1Sjm>/Prkaa2<tm1.1Sjm>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810IC57BL6CBASJLPrkaa1tm11SjmPrkaa1tm11SjmPrkaa2tm11SjmPrkaa2tm11SjmTgMx1cre1Cgn0Prkaa1tm11SjmPrkaa2tm11SjmTgMx1cre1Cgn

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD28222
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28222
• CD00651
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00651