Astrid. Sydow, et.al., Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/21325519

Astrid. Sydow, et.al., Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neuron degeneration_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0003224IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• decreased post-tetanic potentiation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0002922IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• impaired synaptic plasticity_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0001900IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• impaired synaptic plasticity_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman/0
  http://metadb.riken.jp/0001900IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280I277PI308PlucEman0TgCamk2atTA1MmayTgtetOMAPTK280I277PI308PlucEman
• abnormal paired-pulse facilitation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman/0
  http://metadb.riken.jp/0002918IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280I277PI308PlucEman0TgCamk2atTA1MmayTgtetOMAPTK280I277PI308PlucEman
• impaired passive avoidance behavior_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0004000IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• decreased post-tetanic potentiation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman/0
  http://metadb.riken.jp/0002922IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280I277PI308PlucEman0TgCamk2atTA1MmayTgtetOMAPTK280I277PI308PlucEman
• neurofibrillary tangles_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0003214IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• tau protein deposits_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0004250IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• astrocytosis_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0003354IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• impaired spatial learning_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0012307IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• impaired coordination_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0001405IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• abnormal synapse morphology_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0009538IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay
• reduced long term potentiation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*K280,-luc)#Eman/0
  http://metadb.riken.jp/0001473IC57BL6TgCamk2atTA1Mmay0TgtetOMAPTK280lucEman0TgtetOMAPTK280lucEmanTgCamk2atTA1Mmay