Chaoshe. Guo, et.al., A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21364285

Chaoshe. Guo, et.al., A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis., The Journal of clinical investigation, 2011, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Six1<tm1(cre,ALPP)Xli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5014213

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cervical aortic arch_Fgf8<tm1.3Mrt>/Fgf8<+>,Six1<tm1(cre,ALPP)Xli>/Six1<+>
  http://metadb.riken.jp/0004161I129129P2OlaHsdC57BL6Fgf8tm13MrtFgf8Six1tm1creALPPXliSix1Six1tm1creALPPXliFgf8Six1Fgf8tm13Mrt
• retroesophageal right subclavian artery_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0004160I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmEya1tm1Rilm
• vascular ring_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<+>
  http://metadb.riken.jp/0010466I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1Six1Eya1tm1RilmSix1tm1Mair
• double outlet right ventricle_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0000284I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal cardiovascular development_Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0002925I129C57BL6CD1SJLSix1tm1MairSix1tm1MairSix1tm1Mair
• interrupted aortic arch_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0004157I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• increased apoptosis_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0006042I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• interrupted aortic arch_Fgf8<tm1.3Mrt>/Fgf8<+>,Six1<tm1(cre,ALPP)Xli>/Six1<+>
  http://metadb.riken.jp/0004157I129129P2OlaHsdC57BL6Fgf8tm13MrtFgf8Six1tm1creALPPXliSix1Six1tm1creALPPXliFgf8Six1Fgf8tm13Mrt
• abnormal skeletal muscle morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0000759I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal cardiac outflow tract development_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0006126I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• right aortic arch_Eya1<tm1Rilm>/Eya1<+>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0004158I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1Six1tm1MairSix1tm1MairEya1Six1tm1MairEya1tm1Rilm
• abnormal craniofacial development_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0003935I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• interrupted aortic arch_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<+>
  http://metadb.riken.jp/0004157I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1Six1Eya1tm1RilmSix1tm1Mair
• abnormal skeletal muscle morphology_Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0000759I129S1Sv129X1SvJC57BL6Six1tm1MairSix1tm1MairSix1tm1Mair
• double outlet right ventricle_Eya1<tm1Rilm>/Eya1<+>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0000284I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1Six1tm1MairSix1tm1MairEya1Six1tm1MairEya1tm1Rilm
• right aortic arch_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0004158I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal tongue muscle morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0004136I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• retroesophageal right subclavian artery_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<+>
  http://metadb.riken.jp/0004160I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1Six1Eya1tm1RilmSix1tm1Mair
• interrupted aortic arch_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0004157I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmEya1tm1Rilm
• abnormal cardiac outflow tract development_Fgf8<tm1.3Mrt>/Fgf8<+>,Six1<tm1(cre,ALPP)Xli>/Six1<+>
  http://metadb.riken.jp/0006126I129129P2OlaHsdC57BL6Fgf8tm13MrtFgf8Six1tm1creALPPXliSix1Six1tm1creALPPXliFgf8Six1Fgf8tm13Mrt
• abnormal facial morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0003743I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal craniofacial development_Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0003935I129S1Sv129X1SvJC57BL6Six1tm1MairSix1tm1MairSix1tm1Mair
• micrognathia_Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0002639I129S1Sv129X1SvJC57BL6Six1tm1MairSix1tm1MairSix1tm1Mair
• abnormal common carotid artery morphology_Eya1<tm1Rilm>/Eya1<+>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0012729I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1Six1tm1MairSix1tm1MairEya1Six1tm1MairEya1tm1Rilm
• abnormal cardiac outflow tract development_Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0006126I129S1Sv129X1SvJC57BL6Six1tm1MairSix1tm1MairSix1tm1Mair
• abnormal pulmonary artery morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0000484I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal cardiac outflow tract development_Eya1<tm1Rilm>/Eya1<+>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0006126I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1Six1tm1MairSix1tm1MairEya1Six1tm1MairEya1tm1Rilm
• abnormal cardiovascular development_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0002925I129C57BL6CD1SJLEya1tm1RilmEya1tm1RilmEya1tm1Rilm
• double outlet right ventricle_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<+>
  http://metadb.riken.jp/0000284I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1Six1Eya1tm1RilmSix1tm1Mair
• abnormal common carotid artery morphology_Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0012729I129S1Sv129X1SvJC57BL6Six1tm1MairSix1tm1MairSix1tm1Mair
• abnormal cardiac outflow tract development_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<+>
  http://metadb.riken.jp/0006126I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1Six1Eya1tm1RilmSix1tm1Mair
• abnormal cardiovascular development_Tbx1<tm1Bem>/Tbx1<+>
  http://metadb.riken.jp/0002925I129C57BL6CD1SJLTbx1tm1BemTbx1Tbx1tm1BemTbx1
• abnormal cardiovascular development_Six1<tm1Mair>/Six1<tm1Mair>,Tbx1<tm1Bem>/Tbx1<tm1Bem>
  http://metadb.riken.jp/0002925I129C57BL6CD1SJLSix1tm1MairSix1tm1MairTbx1tm1BemTbx1tm1BemSix1tm1MairTbx1tm1Bem
• abnormal craniofacial development_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0003935I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmEya1tm1Rilm
• retroesophageal right subclavian artery_Eya1<tm1Rilm>/Eya1<+>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0004160I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1Six1tm1MairSix1tm1MairEya1Six1tm1MairEya1tm1Rilm
• abnormal cardiovascular development_Eya1<tm1Rilm>/Eya1<+>,Tbx1<tm1Bem>/Tbx1<+>
  http://metadb.riken.jp/0002925I129C57BL6CD1SJLEya1tm1RilmEya1Tbx1tm1BemTbx1Eya1Tbx1Tbx1tm1BemEya1tm1Rilm
• retroesophageal right subclavian artery_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0004160I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal cardiovascular development_Tbx1<tm1Bem>/Tbx1<tm1Bem>
  http://metadb.riken.jp/0002925I129C57BL6CD1SJLTbx1tm1BemTbx1tm1BemTbx1tm1Bem
• abnormal skeletal muscle morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0000759I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmEya1tm1Rilm
• persistent truncus arteriosis_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0002633I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• persistent truncus arteriosis_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Tbx1<tm1Bem>/Tbx1<+>
  http://metadb.riken.jp/0002633I129C57BL6CD1SJLEya1tm1RilmEya1tm1RilmTbx1tm1BemTbx1Tbx1Tbx1tm1BemEya1tm1Rilm
• abnormal extraocular muscle morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0005247I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• decreased cell proliferation_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0000352I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• vascular ring_Eya1<tm1Rilm>/Eya1<tm1Rilm>,Six1<tm1Mair>/Six1<tm1Mair>
  http://metadb.riken.jp/0010466I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmSix1tm1MairSix1tm1MairEya1tm1RilmSix1tm1Mair
• abnormal aortic arch morphology_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0004113I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmEya1tm1Rilm
• vascular ring_Eya1<tm1Rilm>/Eya1<tm1Rilm>
  http://metadb.riken.jp/0010466I129S1Sv129X1SvJC57BL6Eya1tm1RilmEya1tm1RilmEya1tm1Rilm

class

http://purl.org/net/cito/citesAsAuthority

• Six1<tm1(cre,ALPP)Xli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5014213