Melinda L. Angus-Hill, et.al., T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/21383188

Melinda L. Angus-Hill, et.al., T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946911
• Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946909
• Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946910
• Tcf7l2<tm1(EGFP/cre)Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946918

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal crypts of Lieberkuhn morphology_Tcf7l2<tm1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0000490NSTcf7l2tm1EGFPcreMrcTcf7l2tm21MrcTcf7l2tm1EGFPcreMrcTcf7l2tm21Mrc
• absent gastric milk in neonates_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0009546NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• embryo tissue necrosis_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0013241I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• abnormal small intestine goblet cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0013792NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• neonatal lethality, complete penetrance_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0011087I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• abnormal small intestine morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0000496NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal colon morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0000495NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal intestinal enteroendocrine cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0010802I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• abnormal colon morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000495I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• increased intestinal adenoma incidence_Apc<Min>/Apc<+>,Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<+>
  http://metadb.riken.jp/0002404IC57BL6JApcMinApcTcf7l2tm11EGFPcreMrcTcf7l2Tcf7l2ApcApcMinTcf7l2tm11EGFPcreMrc
• abnormal intestinal enteroendocrine cell morphology_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0010802I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• abnormal crypts of Lieberkuhn morphology_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000490I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• embryo tissue necrosis_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0013241NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal intestine morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0000477NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal enterocyte proliferation_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0008883NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal small intestine morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0000496NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• decreased birth weight_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0009674NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal colon morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0000495NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal intestinal enteroendocrine cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0010802NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal intestine morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0000477NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal enterocyte proliferation_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0008883NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal crypts of Lieberkuhn morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0000490NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• decreased birth weight_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0009674NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• embryo tissue necrosis_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0013241I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• abnormal crypts of Lieberkuhn morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0000490NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal small intestine morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000496I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• abnormal enterocyte proliferation_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0008883I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• neonatal lethality, complete penetrance_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0011087NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal enterocyte proliferation_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0008883I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• decreased body size_Tcf7l2<tm1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0001265NSTcf7l2tm1EGFPcreMrcTcf7l2tm21MrcTcf7l2tm1EGFPcreMrcTcf7l2tm21Mrc
• abnormal intestinal goblet cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0003449I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• decreased birth weight_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0009674I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• neonatal lethality, complete penetrance_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0011087NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal small intestine morphology_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000496I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• increased intestinal adenoma incidence_Apc<Min>/Apc<+>,Tcf7l2<tm2.2Mrc>/Tcf7l2<+>
  http://metadb.riken.jp/0002404IC57BL6JApcMinApcTcf7l2tm22MrcTcf7l2Tcf7l2tm22MrcApcMinTcf7l2Apc
• abnormal crypts of Lieberkuhn morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000490I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• abnormal intestinal goblet cell morphology_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0003449I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• abnormal intestinal enteroendocrine cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0010802NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• absent gastric milk in neonates_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0009546NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• abnormal intestine morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000477I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• abnormal intestinal goblet cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/0003449NSTcf7l2tm11EGFPcreMrcTcf7l2tm21MrcTcf7l2tm11EGFPcreMrcTcf7l2tm21Mrc
• decreased birth weight_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0009674I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• embryo tissue necrosis_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0013241NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc
• abnormal colon morphology_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000495I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• absent gastric milk in neonates_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0009546I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• absent gastric milk in neonates_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0009546I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• neonatal lethality, complete penetrance_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0011087I129S1SvTcf7l2tm11EGFPcreMrcTcf7l2tm22MrcTcf7l2tm11EGFPcreMrcTcf7l2tm22Mrc
• abnormal intestine morphology_Tcf7l2<tm2.2Mrc>/Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/0000477I129S1SvTcf7l2tm22MrcTcf7l2tm22MrcTcf7l2tm22Mrc
• abnormal colon goblet cell morphology_Tcf7l2<tm1.1(EGFP/cre)Mrc>/Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/0013795NSTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrcTcf7l2tm11EGFPcreMrc

class

http://purl.org/net/cito/citesAsAuthority

• Tcf7l2<tm2.2Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946911
• Tcf7l2<tm1.1(EGFP/cre)Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946909
• Tcf7l2<tm2.1Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946910
• Tcf7l2<tm1(EGFP/cre)Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946918