Xiao Zhen. Zhou, et.al., The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21436583

Xiao Zhen. Zhou, et.al., The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice., The Journal of clinical investigation, 2011, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013947

class

http://purl.org/net/cito/citesAsAuthority

• Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013947

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased liver tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0008019I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased lymphoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• prenatal lethality, incomplete penetrance_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0011101I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0002038I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• embryonic lethality during organogenesis, complete penetrance_Pinx1<tm1.1Kplu>/Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/0011098I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1tm11KpluPinx1tm11Kplu
• increased lymphoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased liver tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0008019I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• increased mammary gland tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0010299I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased ovary tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008000I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0002020I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased mammary gland tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0010299I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• increased lymphoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• decreased embryo size_Pinx1<tm1.1Kplu>/Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/0001698I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1tm11KpluPinx1tm11Kplu
• pallor_Pinx1<tm1.1Kplu>/Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/0003717I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1tm11KpluPinx1tm11Kplu
• absent heartbeat_Pinx1<tm1.1Kplu>/Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/0004086I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1tm11KpluPinx1tm11Kplu
• increased lung carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0008714I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• anemia_Pinx1<tm1.1Kplu>/Pinx1<tm1.1Kplu>
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1tm11KpluPinx1tm11Kplu
• increased gastrointestinal tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0010279I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• increased lung tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0008014I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased histiocytic sarcoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0009321I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased liver tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008019I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• skin hyperplasia_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0001214I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• premature death_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• increased hepatocellular carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0003331I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• increased gastrointestinal tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0010279I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002020I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased lung tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008014I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased mammary gland tumor incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0010299I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased hemangiosarcoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0003667I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002038I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• abnormal telomere length_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0003155I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• chromosomal instability_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0008866I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0002038I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53tm1BrdPinx1tm11KpluTrp53tm1BrdPinx1
• premature death_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased Harderian gland adenoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0013538I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased sarcoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0002032I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased hibernoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>
  http://metadb.riken.jp/0010344I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Pinx1Pinx1tm11Kplu
• increased lung carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008714I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu
• increased hepatocellular carcinoma incidence_Pinx1<tm1.1Kplu>/Pinx1<+>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0003331I129S7SvEvBrdC57BL6FVBNPinx1tm11KpluPinx1Trp53tm1BrdTrp53Pinx1Trp53tm1BrdTrp53Pinx1tm11Kplu