Prem K. Premsrirut, et.al., A rapid and scalable system for studying gene function in mice using conditional RNA interference., Cell, 2011, 145

http://rdf.ncbi.nlm.nih.gov/pubmed/21458673

Prem K. Premsrirut, et.al., A rapid and scalable system for studying gene function in mice using conditional RNA interference., Cell, 2011, 145

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm7(tetO-GFP/RNAi:rluc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950590
• Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950583
• Tg(CAG-rtTA3)#Slowe
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950589
• Tg(CAG-rtTA3)4288Slowe
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000298
• Col1a1<tm1(tetO-GFP/RNAi:luc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950574
• Col1a1<tm6(tetO-GFP/RNAi:Cdkn2a)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950585
• Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950582
• Col1a1<tm2(tetO-GFP/RNAi:Trp53)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950577
• Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950584

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm7(tetO-GFP/RNAi:rluc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950590
• Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950583
• Tg(CAG-rtTA3)#Slowe
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950589
• Tg(CAG-rtTA3)4288Slowe
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000298
• Col1a1<tm1(tetO-GFP/RNAi:luc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950574
• Col1a1<tm6(tetO-GFP/RNAi:Cdkn2a)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950585
• Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950582
• Col1a1<tm2(tetO-GFP/RNAi:Trp53)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950577
• Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950584

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• failure of endochondral bone ossification_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008275I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• abnormal hair follicle morphology_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000377I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• hydrops fetalis_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002192I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• short snout_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000445I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• increased lung adenoma incidence_Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(Luc)Kael>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>,Kras<tm4Tyj>/Kras<+>,Tg(Scgb1a1-rtTA)1Jaw/0
  http://metadb.riken.jp/0002048I129S4SvJae129S6SvEvTacC57BL6Col1a1tm5tetOGFPRNAiCdkn2aSloweCol1a1GtROSA26Sortm1LucKaelGtROSA26Sortm1rtTAM2JaeKrastm4TyjKrasTgScgb1a1rtTA1Jaw0TgScgb1a1rtTA1JawGtROSA26Sortm1LucKaelCol1a1tm5tetOGFPRNAiCdkn2aSloweKrastm4TyjKrasCol1a1GtROSA26Sortm1rtTAM2Jae
• increased T cell derived lymphoma incidence_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002024I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• short snout_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000445I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• excessive hair_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000412I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• increased tumor incidence_Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(Luc)Kael>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>,Kras<tm4Tyj>/Kras<+>,Tg(Scgb1a1-rtTA)1Jaw/0
  http://metadb.riken.jp/0002020I129S4SvJae129S6SvEvTacC57BL6Col1a1tm5tetOGFPRNAiCdkn2aSloweCol1a1GtROSA26Sortm1LucKaelGtROSA26Sortm1rtTAM2JaeKrastm4TyjKrasTgScgb1a1rtTA1Jaw0TgScgb1a1rtTA1JawGtROSA26Sortm1LucKaelCol1a1tm5tetOGFPRNAiCdkn2aSloweKrastm4TyjKrasCol1a1GtROSA26Sortm1rtTAM2Jae
• cachexia_Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(Luc)Kael>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>,Kras<tm4Tyj>/Kras<+>,Tg(Scgb1a1-rtTA)1Jaw/0
  http://metadb.riken.jp/0005150I129S4SvJae129S6SvEvTacC57BL6Col1a1tm5tetOGFPRNAiCdkn2aSloweCol1a1GtROSA26Sortm1LucKaelGtROSA26Sortm1rtTAM2JaeKrastm4TyjKrasTgScgb1a1rtTA1Jaw0TgScgb1a1rtTA1JawGtROSA26Sortm1LucKaelCol1a1tm5tetOGFPRNAiCdkn2aSloweKrastm4TyjKrasCol1a1GtROSA26Sortm1rtTAM2Jae
• progressive hair loss_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009004I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• abnormal forelimb morphology_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000550I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• delayed endochondral bone ossification_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003419I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• increased lymphoma incidence_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0012431I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• premature death_Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(Luc)Kael>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>,Kras<tm4Tyj>/Kras<+>,Tg(Scgb1a1-rtTA)1Jaw/0
  http://metadb.riken.jp/0002083I129S4SvJae129S6SvEvTacC57BL6Col1a1tm5tetOGFPRNAiCdkn2aSloweCol1a1GtROSA26Sortm1LucKaelGtROSA26Sortm1rtTAM2JaeKrastm4TyjKrasTgScgb1a1rtTA1Jaw0TgScgb1a1rtTA1JawGtROSA26Sortm1LucKaelCol1a1tm5tetOGFPRNAiCdkn2aSloweKrastm4TyjKrasCol1a1GtROSA26Sortm1rtTAM2Jae
• fetal growth retardation_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004201I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• postnatal growth retardation_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001732I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• premature death_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• increased T cell derived lymphoma incidence_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002024I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• decreased body size_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001265I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• decreased body size_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001265I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• increased leukemia incidence_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002026I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• no abnormal phenotype detected_Col1a1<tm1(tetO-GFP/RNAi:luc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002169I129S4SvJaeC57BL6Col1a1tm1tetOGFPRNAilucSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1Col1a1tm1tetOGFPRNAilucSloweGtROSA26Sortm1rtTAM2JaeGtROSA26Sor
• postnatal growth retardation_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001732I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• polydactyly_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000562I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• increased leukemia incidence_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002026I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• abnormal hair follicle morphology_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000377I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• abnormal hindlimb morphology_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000556I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• premature death_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• increased lymphoma incidence_Col1a1<tm3(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0012431I129S4SvJaeC57BL6Col1a1tm3tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm3tetOGFPRNAiApcSlowe
• progressive hair loss_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009004I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• excessive hair_Col1a1<tm4(tetO-GFP/RNAi:Apc)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000412I129S4SvJaeC57BL6Col1a1tm4tetOGFPRNAiApcSloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm4tetOGFPRNAiApcSloweGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1
• respiratory distress_Col1a1<tm5(tetO-GFP/RNAi:Cdkn2a)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(Luc)Kael>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>,Kras<tm4Tyj>/Kras<+>,Tg(Scgb1a1-rtTA)1Jaw/0
  http://metadb.riken.jp/0001954I129S4SvJae129S6SvEvTacC57BL6Col1a1tm5tetOGFPRNAiCdkn2aSloweCol1a1GtROSA26Sortm1LucKaelGtROSA26Sortm1rtTAM2JaeKrastm4TyjKrasTgScgb1a1rtTA1Jaw0TgScgb1a1rtTA1JawGtROSA26Sortm1LucKaelCol1a1tm5tetOGFPRNAiCdkn2aSloweKrastm4TyjKrasCol1a1GtROSA26Sortm1rtTAM2Jae