David. Ramonet, et.al., Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2., PloS one, 2011, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/21494637

David. Ramonet, et.al., Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2., PloS one, 2011, 6

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(PDGFB-LRRK2*G2019S)340Djmo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950671
• Tg(PDGFB-LRRK2*R1441C)574Djmo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950673

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating noradrenaline level_Tg(PDGFB-LRRK2*R1441C)574Djmo/0
  http://metadb.riken.jp/0005664IC3HHeJC57BL6JTgPDGFBLRRK2R1441C574Djmo0TgPDGFBLRRK2R1441C574Djmo
• abnormal neuron morphology_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0002882IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• abnormal homeostasis_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0001764IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• abnormal neurite morphology_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0008415IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• decreased dopaminergic neuron number_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0011448IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• decreased dopamine level_Tg(PDGFB-LRRK2*R1441C)574Djmo/0
  http://metadb.riken.jp/0005643IC3HHeJC57BL6JTgPDGFBLRRK2R1441C574Djmo0TgPDGFBLRRK2R1441C574Djmo
• abnormal neuron morphology_Tg(PDGFB-LRRK2*R1441C)574Djmo/0
  http://metadb.riken.jp/0002882IC3HHeJC57BL6JTgPDGFBLRRK2R1441C574Djmo0TgPDGFBLRRK2R1441C574Djmo
• increased serotonin level_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0010069IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• decreased vertical activity_Tg(PDGFB-LRRK2*R1441C)574Djmo/0
  http://metadb.riken.jp/0002757IC3HHeJC57BL6JTgPDGFBLRRK2R1441C574Djmo0TgPDGFBLRRK2R1441C574Djmo
• abnormal autophagy_Tg(PDGFB-LRRK2*R1441C)574Djmo/0
  http://metadb.riken.jp/0008260IC3HHeJC57BL6JTgPDGFBLRRK2R1441C574Djmo0TgPDGFBLRRK2R1441C574Djmo
• abnormal axon morphology_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0005404IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• abnormal autophagy_Tg(PDGFB-LRRK2*G2019S)340Djmo/0
  http://metadb.riken.jp/0008260IC3HHeJC57BL6JTgPDGFBLRRK2G2019S340Djmo0TgPDGFBLRRK2G2019S340Djmo
• hypoactivity_Tg(PDGFB-LRRK2*R1441C)574Djmo/0
  http://metadb.riken.jp/0001402IC3HHeJC57BL6JTgPDGFBLRRK2R1441C574Djmo0TgPDGFBLRRK2R1441C574Djmo

class

http://purl.org/net/cito/citesAsAuthority

• Tg(PDGFB-LRRK2*G2019S)340Djmo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950671
• Tg(PDGFB-LRRK2*R1441C)574Djmo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950673