Emilie A. Bard-Chapeau, et.al., Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis., Cancer cell, 2011, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/21575863

Emilie A. Bard-Chapeau, et.al., Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis., Cancer cell, 2011, 19

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating alanine transaminase level_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Stat3<tm1Vpo>/Stat3<tm1Vpo>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129P2OlaHsd129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfStat3tm1VpoStat3tm1VpoTgAlbcre21Mgn0Stat3tm1VpoTgAlbcre21MgnPtpn11tm1Gsf
• weight loss_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001263I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• hepatic necrosis_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001654I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• abnormal liver parenchyma morphology_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008986I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• abnormal liver morphology_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000598I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased incidence of tumors by chemical induction_Stat3<tm1Vpo>/Stat3<tm1Vpo>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004499I129P2OlaHsdC57BL6DBAStat3tm1VpoStat3tm1VpoTgAlbcre21Mgn0Stat3tm1VpoTgAlbcre21Mgn
• increased incidence of tumors by chemical induction_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Stat3<tm1Vpo>/Stat3<tm1Vpo>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004499I129P2OlaHsd129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfStat3tm1VpoStat3tm1VpoTgAlbcre21Mgn0Stat3tm1VpoTgAlbcre21MgnPtpn11tm1Gsf
• liver hyperplasia_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005141I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• liver fibrosis_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• abnormal hepatocyte morphology_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000607I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased circulating aspartate transaminase level_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005343I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased circulating interleukin-6 level_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008596I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• focal hepatic necrosis_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001656I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased incidence of tumors by chemical induction_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004499I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased circulating alanine transaminase level_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased hepatocyte proliferation_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased liver adenoma incidence_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003324I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• liver inflammation_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Stat3<tm1Vpo>/Stat3<tm1Vpo>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001860I129P2OlaHsd129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfStat3tm1VpoStat3tm1VpoTgAlbcre21Mgn0Stat3tm1VpoTgAlbcre21MgnPtpn11tm1Gsf
• liver inflammation_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001860I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn
• increased acute inflammation_Ptpn11<tm1Gsf>/Ptpn11<tm1Gsf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005088I129S1Sv129X1SvJC57BL6DBAPtpn11tm1GsfPtpn11tm1GsfTgAlbcre21Mgn0Ptpn11tm1GsfTgAlbcre21Mgn