Kirk. Cunningham, et.al., Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations., Human molecular genetics, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21596842

Kirk. Cunningham, et.al., Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations., Human molecular genetics, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ccm2<tm1Sbn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085314
• Ccm2<tm2.1Sbn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085315

class

http://purl.org/net/cito/citesAsAuthority

• Ccm2<tm1Sbn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085314
• Ccm2<tm2.1Sbn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085315

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal angiogenesis_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0000260IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal heart development_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0000267IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal heart development_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0000267IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• abnormal head morphology_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0000432IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• ataxia_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001393IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• pericardial edema_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0001787IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
他24件を見る
• intracranial hemorrhage_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001915IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• intracerebral hemorrhage_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001916IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• seizures_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002064IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• premature death_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• abnormal astrocyte morphology_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002182IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• abnormal vascular branching morphogenesis_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0003227IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal vascular branching morphogenesis_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0003227IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• abnormal artery development_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0003410IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal artery development_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0003410IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• embryonic growth retardation_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0003984IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• abnormal vitelline vascular remodeling_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0004076IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal vitelline vascular remodeling_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0004076IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• failure of heart looping_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0004251IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• failure of heart looping_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0004251IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• abnormal dorsal aorta morphology_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0004787IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• abnormal brain vasculature morphology_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004950IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• abnormal blood-brain barrier function_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005167IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• abnormal vascular smooth muscle morphology_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0005592IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal vascular smooth muscle morphology_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0005592IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• cerebellum hemorrhage_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006052IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• microgliosis_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008918IC57BL6CBACcm2tm21SbnCcm2tm21SbnTgMx1cre1Cgn0Ccm2tm21SbnTgMx1cre1Cgn
• abnormal developmental vascular remodeling_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0009577IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn
• abnormal developmental vascular remodeling_Ccm2<tm2.1Sbn>/Ccm2<tm2.1Sbn>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0009577IC57BL6SJLCcm2tm21SbnCcm2tm21SbnTgTekcre1Ywa0Ccm2tm21SbnTgTekcre1Ywa
• embryonic lethality during organogenesis, complete penetrance_Ccm2<tm1Sbn>/Ccm2<tm1Sbn>
  http://metadb.riken.jp/0011098IC57BL6Ccm2tm1SbnCcm2tm1SbnCcm2tm1Sbn