Doreswamy. Kenchegowda, et.al., Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells., Developmental biology, 2011, 356

http://rdf.ncbi.nlm.nih.gov/pubmed/21600198

Doreswamy. Kenchegowda, et.al., Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells., Developmental biology, 2011, 356

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal palpebral conjunctiva morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013394IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• lacrimal gland necrosis_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0014147IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal Meibomian gland acinus morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0009935IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• decreased corneal stroma thickness_Klf4<tm1Khk>/Klf4<tm1Khk>,Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0003092I129S6SvEvTacFVBKlf4tm1KhkKlf4tm1KhkKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1PgrKlf4tm1Khk
• enlarged hair follicles_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0000381IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• anterior iris synechia_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0011481IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• small lens_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001306IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal Meibomian gland physiology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013391IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• absent conjunctiva goblet cells_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013527IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal conjunctival epithelium morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0004481IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• increased cell proliferation_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0000351IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal iris morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001322IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal eyelid aperture_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0003671IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• posterior iris synechia_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0011482IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal conjunctival epithelium morphology_Klf4<tm1Khk>/Klf4<tm1Khk>,Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0004481I129S6SvEvTacFVBKlf4tm1KhkKlf4tm1KhkKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1PgrKlf4tm1Khk
• abnormal extraocular muscle morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0005247IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• eyelid edema_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0006167IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal corneal stroma morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0005300IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal eyelid morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001340IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• enlarged sebaceous gland_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0000652IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal Meibomian gland development_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013385IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• increased corneal stroma thickness_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0009742IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• disorganized secondary lens fibers_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0002579IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• small pupils_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001320IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal ocular surface morphology_Klf4<tm1Khk>/Klf4<tm1Khk>,Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013754I129S6SvEvTacFVBKlf4tm1KhkKlf4tm1KhkKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1PgrKlf4tm1Khk
• abnormal corneal epithelium morphology_Klf4<tm1Khk>/Klf4<tm1Khk>,Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0006000I129S6SvEvTacFVBKlf4tm1KhkKlf4tm1KhkKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1PgrKlf4tm1Khk
• absent conjunctiva goblet cells_Klf4<tm1Khk>/Klf4<tm1Khk>,Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013527I129S6SvEvTacFVBKlf4tm1KhkKlf4tm1KhkKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1PgrKlf4tm1Khk
• eyelids fail to open_Klf4<tm1Khk>/Klf4<tm1Khk>,Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0005176I129S6SvEvTacFVBKlf4tm1KhkKlf4tm1KhkKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1PgrKlf4tm1Khk
• narrow eye opening_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0005287IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• microphthalmia_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001297IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal corneal epithelium morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0006000IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal lens morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001303IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal cornea morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001312IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• corneal opacity_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001314IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal ocular surface morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0013754IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal lacrimal gland morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0001346IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• abnormal lens epithelium morphology_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0003237IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• increased cornea thickness_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0011962IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr
• lacrimal gland inflammation_Klf5<tm1Jaw>/Klf5<tm1Jaw>,Tg(Pax6-cre,GFP)1Pgr/0
  http://metadb.riken.jp/0008880IFVBKlf5tm1JawKlf5tm1JawTgPax6creGFP1Pgr0Klf5tm1JawTgPax6creGFP1Pgr