Kelly. Moran-Crusio, et.al., Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation., Cancer cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21723200

Kelly. Moran-Crusio, et.al., Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation., Cancer cell, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tet2<tm1.1Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5141120

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000691I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• extramedullary hematopoiesis_Tet2<tm1.1Iaai>/Tet2<+>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000240I129SSvEvC57BL6Tet2tm11IaaiTet2TgVav1cre1Graf0Tet2TgVav1cre1GrafTet2tm11Iaai
• increased chronic myelocytic leukemia incidence_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005481I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• abnormal myeloid leukocyte morphology_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0008250I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• increased leukocyte cell number_Tet2<tm1.1Iaai>/Tet2<+>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000218I129SSvEvC57BL6Tet2tm11IaaiTet2TgVav1cre1Graf0Tet2TgVav1cre1GrafTet2tm11Iaai
• increased hematopoietic cell number_Tet2<tm1.1Iaai>/Tet2<+>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0011181I129SSvEvC57BL6Tet2tm11IaaiTet2TgVav1cre1Graf0Tet2TgVav1cre1GrafTet2tm11Iaai
• abnormal hematopoietic stem cell physiology_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0010763I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• myeloid hyperplasia_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0010373I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• no abnormal phenotype detected_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(EIIa-cre)C5379Lmgd/0
  http://metadb.riken.jp/0002169I129SSvEvC57BL6FVBNTet2tm11IaaiTet2tm11IaaiTgEIIacreC5379Lmgd0Tet2tm11IaaiTgEIIacreC5379Lmgd
• extramedullary hematopoiesis_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000240I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• increased monocyte cell number_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000220I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• increased leukocyte cell number_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000218I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• increased monocyte cell number_Tet2<tm1.1Iaai>/Tet2<+>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000220I129SSvEvC57BL6Tet2tm11IaaiTet2TgVav1cre1Graf0Tet2TgVav1cre1GrafTet2tm11Iaai
• increased hematopoietic cell number_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0011181I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• abnormal hematopoietic stem cell physiology_Tet2<tm1.1Iaai>/Tet2<+>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0010763I129SSvEvC57BL6Tet2tm11IaaiTet2TgVav1cre1Graf0Tet2TgVav1cre1GrafTet2tm11Iaai
• increased spleen weight_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0004952I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• abnormal common myeloid progenitor cell morphology_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0006410I129SSvEvC57BL6Tet2tm11IaaiTet2tm11IaaiTgVav1cre1Graf0Tet2tm11IaaiTgVav1cre1Graf
• abnormal hematopoietic stem cell physiology_Tet2<tm1.1Iaai>/Tet2<tm1.1Iaai>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010763I129SSvEvC57BL6CBATet2tm11IaaiTet2tm11IaaiTgMx1cre1Cgn0TgMx1cre1CgnTet2tm11Iaai

class

http://purl.org/net/cito/citesAsAuthority

• Tet2<tm1.1Iaai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5141120