Cyril. Quivoron, et.al., TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis., Cancer cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21723201

Cyril. Quivoron, et.al., TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis., Cancer cell, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tet2<tm1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5141225

class

http://purl.org/net/cito/citesAsAuthority

• Tet2<tm1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5141225

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0001263B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• abnormal liver sinusoid morphology_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008989IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• enlarged liver_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0000599B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• abnormal monocyte differentiation_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0008112B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• increased leukocyte cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• increased leukocyte cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0000218B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• premature death_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0002083B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• increased hematopoietic stem cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0004809B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• premature death_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0002083B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• anemia_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0001577B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased DN1 thymic pro-T cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0010129B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased double-negative T cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0005090B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased B cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005014IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• liver fibrosis_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0003333B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• increased B cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0005014B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• weight loss_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0001263B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• enlarged liver_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• abnormal spleen morphology_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000689IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• decreased pro-B cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008208IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• increased B cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0005014B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• anemia_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0001577B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• enlarged liver_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0000599B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• abnormal proerythroblast morphology_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002416IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• decreased pre-B cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008209IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• enlarged spleen_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0000691B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• decreased erythrocyte cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0002875B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• enlarged spleen_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• decreased pro-B cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0008208B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased double-negative T cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005090IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• increased monocyte cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0000220B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• abnormal common myeloid progenitor cell morphology_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006410IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• thrombocytopenia_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0003179B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• extramedullary hematopoiesis_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000240IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• liver inflammation_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0001860B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased erythroid progenitor cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0003135B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• abnormal spleen morphology_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0000689B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• decreased erythrocyte cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0002875B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• liver inflammation_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0001860B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• abnormal spleen morphology_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0000689B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• decreased erythrocyte cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• extramedullary hematopoiesis_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0000240B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• thrombocytopenia_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003179IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• increased spleen red pulp amount_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008476IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• increased hematopoietic stem cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• decreased pre-B cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0008209B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• abnormal monocyte differentiation_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0008112B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• abnormal common myeloid progenitor cell morphology_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0006410B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• thrombocytopenia_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0003179B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• increased DN1 thymic pro-T cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010129IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• increased erythroblast number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0011178IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics
• enlarged spleen_Tet2<Gt(AN0709)Wtsi>/Tet2<+>
  http://metadb.riken.jp/0000691B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2Tet2GtAN0709WtsiTet2
• increased erythroid progenitor cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0003135B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased leukocyte cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0000218B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased monocyte cell number_Tet2<Gt(AN0709)Wtsi>/Tet2<Gt(AN0709)Wtsi>
  http://metadb.riken.jp/0000220B6129P2Tet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709WtsiTet2GtAN0709Wtsi
• increased monocyte cell number_Tet2<tm1Ics>/Tet2<tm1Ics>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000220IC57BL6CBATet2tm1IcsTet2tm1IcsTgMx1cre1Cgn0TgMx1cre1CgnTet2tm1Ics