Yunyuan V. Wang, et.al., Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity., Genes & development, 2011, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/21724834

Yunyuan V. Wang, et.al., Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity., Genes & development, 2011, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cdkn1a<tm1Hpw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285186

class

http://purl.org/net/cito/citesAsAuthority

• Cdkn1a<tm1Hpw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285186

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• pallor_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003717I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• decreased bone marrow cell number_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0000333I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• decreased erythrocyte cell number_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0002875I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• spleen atrophy_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003643I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• decreased erythrocyte cell number_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0002875I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• increased mortality induced by ionizing radiation_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003992I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• increased mortality induced by ionizing radiation_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003992I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• thrombocytopenia_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003179I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• decreased hematocrit_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0000208I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• small thymus_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0000706I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• enlarged heart_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0000274I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• abnormal hematopoietic stem cell physiology_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0010763I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• decreased leukocyte cell number_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0000221I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• decreased common myeloid progenitor cell number_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0008813I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• decreased leukocyte cell number_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0000221I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• decreased spleen red pulp amount_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0008477I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• thrombocytopenia_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003179I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• abnormal bone marrow morphology_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0002397I129S4SvJae129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm2WahlTrp53tm2WahlMdm2tm1GloTrp53tm2WahlMdm2
• decreased mortality induced by ionizing radiation_Cdkn1a<tm1Hpw>/Cdkn1a<+>,Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0003010I129S4SvJae129X1SvJC57BL6Cdkn1atm1HpwCdkn1aTrp53tm2WahlTrp53tm2WahlCdkn1atm1HpwCdkn1aTrp53tm2Wahl
• increased heart weight_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0002833I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• abnormal definitive hematopoiesis_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0002123I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• abnormal megakaryocyte progenitor cell morphology_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0002413I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl
• decreased erythroid progenitor cell number_Trp53<tm2Wahl>/Trp53<tm2Wahl>
  http://metadb.riken.jp/0008973I129S4SvJaeC57BL6Trp53tm2WahlTrp53tm2WahlTrp53tm2Wahl