Daniel. Holl, et.al., Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia., PloS one, 2011, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/21779369

Daniel. Holl, et.al., Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia., PloS one, 2011, 6

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(tetO-Tcfap2c)Hsc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4949113

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(tetO-Tcfap2c)Hsc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4949113

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal circulating enzyme level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001570I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased circulating amylase level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008806I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal pancreas physiology_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002693I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased circulating alanine transaminase level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002941I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased circulating aspartate transaminase level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005343I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• weight loss_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal intestine development_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010158I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased hepatocyte proliferation_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003893I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal enterocyte proliferation_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008883I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• lethargy_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005202I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal intestinal mucosa morphology_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000511I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased circulating alkaline phosphatase level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002968I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• liver failure_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003326I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• decreased liver glycogen level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010398I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased lactate dehydrogenase level_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002944I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal hepatocyte morphology_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000607I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• dehydration_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001429I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• hepatic steatosis_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002628I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• premature death_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased hepatocyte apoptosis_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003887I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal small intestine morphology_Col1a1<tm1(tetO-Tcfap2c)Hsc>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000496I129S4SvJaeC57BL6Col1a1tm1tetOTcfap2cHscCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOTcfap2cHscGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae