Malini. Mukherjee, et.al., Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice., PloS one, 2011, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/21799785

Malini. Mukherjee, et.al., Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice., PloS one, 2011, 6

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased lymphoma incidence_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0012431B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• premature death_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002083B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• increased carcinoma incidence_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002038B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• increased splenocyte proliferation_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009336B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• altered tumor pathology_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0010639B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• embryonic lethality between implantation and somite formation_Espl1<Gt(XL058)Byg>/Espl1<Gt(XL058)Byg>
  http://metadb.riken.jp/0006205B6129P2Espl1GtXL058BygEspl1GtXL058BygEspl1GtXL058BygEspl1GtXL058Byg
• abnormal bone marrow cell physiology_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009278B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• decreased tumor incidence_Espl1<Gt(XL058)Byg>/Espl1<+>
  http://metadb.riken.jp/0002052B6129P2Espl1GtXL058BygEspl1GtXL058BygEspl1Espl1Espl1GtXL058Byg
• abnormal splenocyte morphology_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009332B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• increased carcinoma incidence_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002038B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53Trp53Trp53tm1TyjEspl1Espl1GtXL058Byg
• aneuploidy_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0004024B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg
• increased metastatic potential_Espl1<Gt(XL058)Byg>/Espl1<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0001272B6129Trp53tm1TyjEspl1GtXL058BygEspl1GtXL058BygEspl1Trp53tm1TyjTrp53tm1TyjTrp53tm1TyjEspl1Espl1GtXL058Byg