Sutapa. Banerjee, et.al., Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/21896734

Sutapa. Banerjee, et.al., Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(tTA,CMV*1-Rheb,-EGFP)Gtm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5292522

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal astrocyte physiology_Gt(ROSA)26Sor<tm1(tTA,CMV*1-Rheb,-EGFP)Gtm>/Gt(ROSA)26Sor<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0008916IC57BL6CBAGtROSA26Sortm1tTACMV1RhebEGFPGtmGtROSA26SorTgGFAPcreGtm0GtROSA26Sortm1tTACMV1RhebEGFPGtmTgGFAPcreGtmGtROSA26Sor
• premature death_Tsc1<tm1Djk>/Tsc1<tm1Djk>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6CBATsc1tm1DjkTsc1tm1DjkTgGFAPcreGtm0TgGFAPcreGtmTsc1tm1Djk
• abnormal optic nerve morphology_Nf1<tm1Fcr>/Nf1<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001330I129SSvEv129S4SvJaeC57BL6CBANf1tm1FcrNf1TgGFAPcreGtm0TgGFAPcreGtmNf1Nf1tm1Fcr
• seizures_Tsc1<tm1Djk>/Tsc1<tm1Djk>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0002064I129S4SvJaeC57BL6CBATsc1tm1DjkTsc1tm1DjkTgGFAPcreGtm0TgGFAPcreGtmTsc1tm1Djk
• abnormal optic chiasm morphology_Nf1<tm1Fcr>/Nf1<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009770I129SSvEv129S4SvJaeC57BL6CBANf1tm1FcrNf1TgGFAPcreGtm0TgGFAPcreGtmNf1Nf1tm1Fcr
• abnormal astrocyte physiology_Nf1<tm1Par>/Nf1<tm1Par>
  http://metadb.riken.jp/0008916I129S1Sv129X1SvJNf1tm1ParNf1tm1ParNf1tm1Par
• no abnormal phenotype detected_Gt(ROSA)26Sor<tm1(tTA,CMV*1-Rheb,-EGFP)Gtm>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002169NSGtROSA26Sortm1tTACMV1RhebEGFPGtmGtROSA26SorGtROSA26SorGtROSA26Sortm1tTACMV1RhebEGFPGtm
• increased glioma incidence_Nf1<tm1Fcr>/Nf1<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0010278I129SSvEv129S4SvJaeC57BL6CBANf1tm1FcrNf1TgGFAPcreGtm0TgGFAPcreGtmNf1Nf1tm1Fcr
• abnormal neuron proliferation_Nf1<tm1Fcr>/Nf1<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009967I129SSvEv129S4SvJaeC57BL6CBANf1tm1FcrNf1TgGFAPcreGtm0TgGFAPcreGtmNf1Nf1tm1Fcr
• premature death_Nf1<tm1Fcr>/Nf1<+>,Tsc1<tm1Djk>/Tsc1<tm1Djk>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0002083I129SSvEv129S4SvJaeC57BL6CBANf1tm1FcrNf1Tsc1tm1DjkTsc1tm1DjkTgGFAPcreGtm0Nf1tm1FcrNf1Tsc1tm1DjkTgGFAPcreGtm
• abnormal astrocyte physiology_Pten<tm2Mak>/Pten<tm2Mak>
  http://metadb.riken.jp/0008916I129P2OlaHsdPtentm2MakPtentm2MakPtentm2Mak

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(tTA,CMV*1-Rheb,-EGFP)Gtm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5292522

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal astrocyte physiology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020073