Tal I. Arnon, et.al., GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood., Science (New York, N.Y.), 2011, 333

http://rdf.ncbi.nlm.nih.gov/pubmed/21960637

Tal I. Arnon, et.al., GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood., Science (New York, N.Y.), 2011, 333

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• S1pr1<tm1.1Cys>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295051
• S1pr1<tm1Cys>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295050

class

http://purl.org/net/cito/citesAsAuthority

• S1pr1<tm1.1Cys>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295051
• S1pr1<tm1Cys>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295050

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal T cell physiology_Grk2<tm1Gwd>/Grk2<tm1Mca>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002444I129C57BL6DBA2Grk2tm1GwdGrk2tm1McaTgCd4cre1Cwi0TgCd4cre1CwiGrk2tm1McaGrk2tm1Gwd
• increased marginal zone B cell number_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008181I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• increased B cell number_Grk2<tm1Gwd>/Grk2<tm1Mca>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005014I129C57BL6DBA2Grk2tm1GwdGrk2tm1McaTgCd4cre1Cwi0TgCd4cre1CwiGrk2tm1McaGrk2tm1Gwd
• decreased CD8-positive, alpha-beta T cell number_Grk2<tm1Gwd>/Grk2<tm1Mca>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008079I129C57BL6DBA2Grk2tm1GwdGrk2tm1McaTgCd4cre1Cwi0TgCd4cre1CwiGrk2tm1McaGrk2tm1Gwd
• increased B cell number_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005014I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• decreased B cell number_S1pr1<tm1.1Cys>/S1pr1<tm1.1Cys>
  http://metadb.riken.jp/0005017I129P2OlaHsdC3HC57BL6S1pr1tm11CysS1pr1tm11CysS1pr1tm11Cys
• decreased CD4-positive, alpha beta T cell number_Grk2<tm1Gwd>/Grk2<tm1Mca>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008075I129C57BL6DBA2Grk2tm1GwdGrk2tm1McaTgCd4cre1Cwi0TgCd4cre1CwiGrk2tm1McaGrk2tm1Gwd
• abnormal B cell physiology_S1pr1<tm1Cys>/S1pr1<tm1Cys>
  http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6S1pr1tm1CysS1pr1tm1CysS1pr1tm1Cys
• increased CD8-positive, alpha-beta T cell number_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008078I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• impaired leukocyte tethering or rolling_Grk2<tm1Gwd>/Grk2<tm1Mca>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0020332I129C57BL6DBA2Grk2tm1GwdGrk2tm1McaTgCd4cre1Cwi0TgCd4cre1CwiGrk2tm1McaGrk2tm1Gwd
• increased CD4-positive, alpha beta T cell number_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008074I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• decreased B cell number_S1pr1<tm1Cys>/S1pr1<tm1Cys>
  http://metadb.riken.jp/0005017I129P2OlaHsdC57BL6S1pr1tm1CysS1pr1tm1CysS1pr1tm1Cys
• decreased B cell number_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005017I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• increased follicular B cell number_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008173I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• decreased T cell number_Grk2<tm1Gwd>/Grk2<tm1Mca>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005018I129C57BL6DBA2Grk2tm1GwdGrk2tm1McaTgCd4cre1Cwi0TgCd4cre1CwiGrk2tm1McaGrk2tm1Gwd
• abnormal B cell physiology_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002459I129BALBcC57BL6Grk2tm1GwdGrk2tm1GwdCd79atm1creRethCd79aGrk2tm1GwdCd79aCd79atm1creReth
• abnormal B cell physiology_S1pr1<tm1.1Cys>/S1pr1<tm1.1Cys>
  http://metadb.riken.jp/0002459I129P2OlaHsdC3HC57BL6S1pr1tm11CysS1pr1tm11CysS1pr1tm11Cys