Fernando G. Osorio, et.al., Splicing-directed therapy in a new mouse model of human accelerated aging., Science translational medicine, 2011, 3

http://rdf.ncbi.nlm.nih.gov/pubmed/22030750

Fernando G. Osorio, et.al., Splicing-directed therapy in a new mouse model of human accelerated aging., Science translational medicine, 2011, 3

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lmna<tm1.1Otin>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295747
• Lmna<tm1Otin>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295746

class

http://purl.org/net/cito/citesAsAuthority

• Lmna<tm1.1Otin>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295747
• Lmna<tm1Otin>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295746

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Lmna<tm1.1Otin>/Lmna<+>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6Lmnatm11OtinLmnaLmnatm11OtinLmna
• small cranium_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0005352I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal hair follicle morphology_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000377I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal bone structure_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0003795I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased bone trabecula number_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0010869I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased circulating leptin level_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0005668I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• premature aging_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0003786I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• small thymus_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000706I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal cell nucleus morphology_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0003111I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased circulating insulin level_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0002727I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• vascular smooth muscle hypoplasia_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0003814I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal blood homeostasis_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0009642I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased subcutaneous adipose tissue amount_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0008844I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• kyphosis_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000160I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased bone mineral density_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000063I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• prolonged QRS complex duration_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0010392I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• increased circulating growth hormone level_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0005123I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• premature death_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal incisor morphology_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0005358I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• weight loss_Lmna<tm1.1Otin>/Lmna<+>
  http://metadb.riken.jp/0001263I129P2OlaHsdC57BL6Lmnatm11OtinLmnaLmnatm11OtinLmna
• decreased circulating glucose level_Lmna<tm1.1Otin>/Lmna<+>
  http://metadb.riken.jp/0005560I129P2OlaHsdC57BL6Lmnatm11OtinLmnaLmnatm11OtinLmna
• weight loss_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0001263I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal cell nucleus morphology_Lmna<tm1.1Otin>/Lmna<+>
  http://metadb.riken.jp/0003111I129P2OlaHsdC57BL6Lmnatm11OtinLmnaLmnatm11OtinLmna
• infertility_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0001924I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased bone volume_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0010876I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased compact bone thickness_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000135I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• no abnormal phenotype detected_Lmna<tm1Otin>/Lmna<tm1Otin>
  http://metadb.riken.jp/0002169I129P2OlaHsdC57BL6Lmnatm1OtinLmnatm1OtinLmnatm1Otin
• small spleen_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000692I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• abnormal cell physiology_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0005621I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• hypoglycemia_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0000189I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• postnatal growth retardation_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0001732I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased grip strength_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0010053I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• increased adiponectin level_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0004892I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin
• decreased heart rate_Lmna<tm1.1Otin>/Lmna<tm1.1Otin>
  http://metadb.riken.jp/0005333I129P2OlaHsdC57BL6Lmnatm11OtinLmnatm11OtinLmnatm11Otin