Alexander S. Banks, et.al., Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice., Cell metabolism, 2011, 14

http://rdf.ncbi.nlm.nih.gov/pubmed/22055502

Alexander S. Banks, et.al., Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice., Cell metabolism, 2011, 14

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Foxo1<tm1.1Dac>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305498
• Foxo1<tm2.1Dac>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305499

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased respiratory quotient_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0010379NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• absent heartbeat_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0004086NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• abnormal glucose homeostasis_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0002078NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• impaired glucose tolerance_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>,Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0005293B6CgFoxo1tm21DacLeprdbFoxo1tm21DacFoxo1tm21DacLeprdbLeprdbFoxo1tm21DacLeprdb
• abnormal gluconeogenesis_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0003383NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal dorsal aorta morphology_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0004787NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• abnormal vitelline vasculature morphology_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0003229NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• increased circulating glucose level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0005559NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal blood vessel morphology_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0001614NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• decreased energy expenditure_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0004890NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• increased circulating insulin level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0002079NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal somite development_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0001688NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• abnormal lipid homeostasis_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0002118NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal myocardial trabeculae morphology_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0002189NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• increased circulating insulin level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>,Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0002079B6CgFoxo1tm21DacLeprdbFoxo1tm21DacFoxo1tm21DacLeprdbLeprdbFoxo1tm21DacLeprdb
• decreased carbon dioxide production_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0008964NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• decreased circulating triglyceride level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0002644NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal heart development_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0000267NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• absent second pharyngeal arch_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0006345NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• decreased circulating tumor necrosis factor level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0008554B6CgFoxo1tm21DacFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• preweaning lethality, complete penetrance_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0011100NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• decreased circulating VLDL triglyceride level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0003976NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• decreased circulating cholesterol level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0005179NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal embryo development_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0001672NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• abnormal somite shape_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0001691NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• increased percent body fat/body weight_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0005458B6CgFoxo1tm21DacFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• embryonic growth retardation_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0003984NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• decreased somite size_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0011732NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• insulin resistance_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0005331NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• increased circulating insulin level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0002079I129S4SvJaeC57BL6Foxo1tm21DacFoxo1tm21DacInsrtm1DacInsrFoxo1tm21DacInsrtm1DacInsr
• decreased circulating free fatty acid level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0002702NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• insulin resistance_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0005331I129S4SvJaeC57BL6Foxo1tm21DacFoxo1tm21DacInsrtm1DacInsrFoxo1tm21DacInsrtm1DacInsr
• small first pharyngeal arch_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0006341NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• small second pharyngeal arch_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0006344NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• enlarged pericardium_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0000291NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• abnormal adipose tissue physiology_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0005666NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• decreased liver triglyceride level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0009356NSFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• increased susceptibility to diet-induced obesity_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0005658B6CgFoxo1tm21DacFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac
• abnormal heart morphology_Foxo1<tm1.1Dac>/Foxo1<tm1.1Dac>
  http://metadb.riken.jp/0000266NSFoxo1tm11DacFoxo1tm11DacFoxo1tm11Dac
• decreased liver cholesterol level_Foxo1<tm2.1Dac>/Foxo1<tm2.1Dac>
  http://metadb.riken.jp/0010026B6CgFoxo1tm21DacFoxo1tm21DacFoxo1tm21DacFoxo1tm21Dac

class

http://purl.org/net/cito/citesAsAuthority

• Foxo1<tm1.1Dac>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305498
• Foxo1<tm2.1Dac>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305499