Zhenyue. Hao, et.al., The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis., The Journal of experimental medicine, 2012, 209

http://rdf.ncbi.nlm.nih.gov/pubmed/22213803

Zhenyue. Hao, et.al., The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis., The Journal of experimental medicine, 2012, 209

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Huwe1<tm1.1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5314816
• Huwe1<tm1.2Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5314817

class

http://purl.org/net/cito/citesAsAuthority

• Huwe1<tm1.1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5314816
• Huwe1<tm1.2Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5314817

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged heart_Huwe1<tm1.2Mak>/Y
  http://metadb.riken.jp/0000274I129P2OlaHsdBALBcJC57BL6SJLHuwe1tm12MakYHuwe1tm12Mak
• decreased embryo size_Huwe1<tm1.2Mak>/Y
  http://metadb.riken.jp/0001698I129P2OlaHsdBALBcJC57BL6SJLHuwe1tm12MakYHuwe1tm12Mak
• abnormal humoral immune response_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0001800B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased IgM level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0001806B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased IgM level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001806I129P2OlaHsdC57BL6SJLCd79atm1creRethCd79aHuwe1tm11MakYTrp53tm1BrnTrp53tm1BrnTrp53tm1BrnCd79aCd79atm1creRethHuwe1tm11Mak
• decreased IgA level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0001807B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
他19件を見る
• abnormal B cell differentiation_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0002144B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• increased susceptibility to viral infection_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0002418B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• abnormal class switch recombination_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0004816B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• abnormal class switch recombination_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0004816I129P2OlaHsdC57BL6SJLCd79atm1creRethCd79aHuwe1tm11MakYTrp53tm1BrnTrp53tm1BrnTrp53tm1BrnCd79aCd79atm1creRethHuwe1tm11Mak
• decreased B cell proliferation_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0005093B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased follicular B cell number_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008174B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased marginal zone B cell number_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008182B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased transitional stage B cell number_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008190B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• absent B-1a cells_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008203B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• absent B-1a cells_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0008203I129P2OlaHsdC57BL6SJLCd79atm1creRethCd79aHuwe1tm11MakYTrp53tm1BrnTrp53tm1BrnTrp53tm1BrnCd79aCd79atm1creRethHuwe1tm11Mak
• decreased pre-B cell number_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008209B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased mature B cell number_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008211B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased IgG1 level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008495B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased IgG1 level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0008495I129P2OlaHsdC57BL6SJLCd79atm1creRethCd79aHuwe1tm11MakYTrp53tm1BrnTrp53tm1BrnTrp53tm1BrnCd79aCd79atm1creRethHuwe1tm11Mak
• decreased IgG2a level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008496B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• decreased IgG3 level_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008498B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• increased B cell apoptosis_Cd79a<tm1(cre)Reth>/Cd79a<+>,Huwe1<tm1.1Mak>/Y
  http://metadb.riken.jp/0008782B6CgCd79atm1creRethHuwe1tm11MakCd79atm1creRethCd79aHuwe1tm11MakYCd79atm1creRethHuwe1tm11MakCd79a
• embryonic lethality during organogenesis, complete penetrance_Huwe1<tm1.2Mak>/Y
  http://metadb.riken.jp/0011098I129P2OlaHsdBALBcJC57BL6SJLHuwe1tm12MakYHuwe1tm12Mak
• decreased somite size_Huwe1<tm1.2Mak>/Y
  http://metadb.riken.jp/0011732I129P2OlaHsdBALBcJC57BL6SJLHuwe1tm12MakYHuwe1tm12Mak