Lauren T. Gehman, et.al., The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function., Genes & development, 2012, 26

http://rdf.ncbi.nlm.nih.gov/pubmed/22357600

Lauren T. Gehman, et.al., The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function., Genes & development, 2012, 26

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• small cerebellum_Rbfox1<tm1.1Dblk>/Rbfox1<+>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000852I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1Rbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1Rbfox2tm11DblkRbfox1tm11Dblk
• small cerebellum_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000852I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• increased Purkinje cell number_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000879I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• ectopic Purkinje cell_Rbfox1<tm1.1Dblk>/Rbfox1<+>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000885I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1Rbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1Rbfox2tm11DblkRbfox1tm11Dblk
• ectopic Purkinje cell_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000885I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• thin cerebellar molecular layer_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000890I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
他17件を見る
• decreased body weight_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001262I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• decreased body size_Rbfox1<tm1.1Dblk>/Rbfox1<+>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001265I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1Rbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1Rbfox2tm11DblkRbfox1tm11Dblk
• ataxia_Rbfox1<tm1.1Dblk>/Rbfox1<+>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1Rbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1Rbfox2tm11DblkRbfox1tm11Dblk
• impaired coordination_Rbfox1<tm1.1Dblk>/Rbfox1<tm1.1Dblk>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0001405I129C57BL6JRbfox1tm11DblkRbfox1tm11DblkRbfox2tm11DblkRbfox2tm11DblkTgPcp2cre2Mpin0TgPcp2cre2MpinRbfox1tm11DblkRbfox2tm11Dblk
• abnormal posture_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001504I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• hydroencephaly_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001891I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• increased neuron apoptosis_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003203I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• abnormal locomotor activation_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003313I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• abnormal neuron physiology_Rbfox1<tm1.1Dblk>/Rbfox1<tm1.1Dblk>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0004811I129C57BL6JRbfox1tm11DblkRbfox1tm11DblkRbfox2tm11DblkRbfox2tm11DblkTgPcp2cre2Mpin0TgPcp2cre2MpinRbfox1tm11DblkRbfox2tm11Dblk
• abnormal neuron physiology_Rbfox1<tm1.1Dblk>/Rbfox1<+>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004811I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1Rbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1Rbfox2tm11DblkRbfox1tm11Dblk
• abnormal neuron physiology_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004811I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• abnormal Purkinje cell migration_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010008I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• lethality, incomplete penetrance_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010831I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• postnatal lethality, complete penetrance_Rbfox1<tm1.1Dblk>/Rbfox1<+>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011085I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1Rbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1Rbfox2tm11DblkRbfox1tm11Dblk
• postnatal lethality, incomplete penetrance_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011086I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln
• perinatal lethality, complete penetrance_Rbfox1<tm1.1Dblk>/Rbfox1<tm1.1Dblk>,Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011089I129S2SvPasC57BL6C57BL6JSJLRbfox1tm11DblkRbfox1tm11DblkRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0TgNescre1KlnRbfox1tm11DblkRbfox2tm11Dblk
• decreased cerebellar granule cell precursor proliferation_Rbfox2<tm1.1Dblk>/Rbfox2<tm1.1Dblk>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0013551I129S2SvPasC57BL6C57BL6JSJLRbfox2tm11DblkRbfox2tm11DblkTgNescre1Kln0Rbfox2tm11DblkTgNescre1Kln