Sarah. Refaie, et.al., Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion., The Journal of biological chemistry, 2012, 287

http://rdf.ncbi.nlm.nih.gov/pubmed/22396549

Sarah. Refaie, et.al., Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion., The Journal of biological chemistry, 2012, 287

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• intermingled spleen red and white pulp_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008475I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• abnormal peritoneal macrophage morphology_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008244I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased sensitivity to xenobiotic induced morbidity/mortality_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0009766I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased circulating interleukin-10 level_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008593I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• abnormal spleen marginal zone morphology_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0002362I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• decreased T cell number_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0005018I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased interleukin-1 beta secretion_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008657I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• decreased mean systemic arterial blood pressure_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0004876I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• enlarged spleen_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0000691I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased susceptibility to endotoxin shock_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008735I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased circulating interleukin-12 level_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008617I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• abnormal spleen white pulp morphology_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0002357I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased lymphocyte cell number_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0005013I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased circulating interleukin-6 level_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008596I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased circulating tumor necrosis factor level_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008553I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• decreased NK T cell number_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008040I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• abnormal T-helper 1 cell differentiation_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008088I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased circulating interferon-gamma level_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008577I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• increased circulating interleukin-1 beta level_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008641I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs
• decreased follicular dendritic cell number_Pcsk1<tm1Dfs>/Pcsk1<tm1Dfs>
  http://metadb.riken.jp/0008200I129C57BL6JPcsk1tm1DfsPcsk1tm1DfsPcsk1tm1Dfs