Kristin. Kemmerich, et.al., Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice., Nucleic acids research, 2012, 40

http://rdf.ncbi.nlm.nih.gov/pubmed/22447450

Kristin. Kemmerich, et.al., Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice., Nucleic acids research, 2012, 40

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Msh2<tm1Htr>/Msh2<tm1Htr>,Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>,Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0002020I129P2OlaHsdC57BL6C57BL6NMsh2tm1HtrMsh2tm1HtrSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguUngtm1TldUngtm1TldSmug1tm1aEUCOMMHmguUngtm1TldMsh2tm1Htr
• abnormal base-excision repair_Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>,Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0009796I129P2OlaHsdC57BL6C57BL6NSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguUngtm1TldUngtm1TldUngtm1TldSmug1tm1aEUCOMMHmgu
• premature death_Msh2<tm1Htr>/Msh2<tm1Htr>,Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>,Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6C57BL6NMsh2tm1HtrMsh2tm1HtrSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguUngtm1TldUngtm1TldSmug1tm1aEUCOMMHmguUngtm1TldMsh2tm1Htr
• increased lymphoma incidence_Msh2<tm1Htr>/Msh2<tm1Htr>,Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>,Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0012431I129P2OlaHsdC57BL6C57BL6NMsh2tm1HtrMsh2tm1HtrSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguUngtm1TldUngtm1TldSmug1tm1aEUCOMMHmguUngtm1TldMsh2tm1Htr
• abnormal base-excision repair_Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0009796I129P2OlaHsdUngtm1TldUngtm1TldUngtm1Tld
• abnormal mismatch repair_Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>,Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0009797I129P2OlaHsdC57BL6C57BL6NSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguUngtm1TldUngtm1TldUngtm1TldSmug1tm1aEUCOMMHmgu
• preweaning lethality, incomplete penetrance_Msh2<tm1Htr>/Msh2<tm1Htr>,Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>,Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0011110I129P2OlaHsdC57BL6C57BL6NMsh2tm1HtrMsh2tm1HtrSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguUngtm1TldUngtm1TldSmug1tm1aEUCOMMHmguUngtm1TldMsh2tm1Htr
• decreased sensitivity to induced cell death_Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>
  http://metadb.riken.jp/0008944IC57BL6C57BL6NSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmgu
• abnormal base-excision repair_Smug1<tm1a(EUCOMM)Hmgu>/Smug1<tm1a(EUCOMM)Hmgu>
  http://metadb.riken.jp/0009796IC57BL6C57BL6NSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmguSmug1tm1aEUCOMMHmgu
• increased sensitivity to induced cell death_Ung<tm1Tld>/Ung<tm1Tld>
  http://metadb.riken.jp/0008943I129P2OlaHsdUngtm1TldUngtm1TldUngtm1Tld