Miguel. Ganuza, et.al., Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion., The EMBO journal, 2012, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/22505032

Miguel. Ganuza, et.al., Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion., The EMBO journal, 2012, 31

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cdk7<Gt(D032B11)1.1Wrst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5429213

class

http://purl.org/net/cito/citesAsAuthority

• Cdk7<Gt(D032B11)1.1Wrst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5429213

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased bone mineral content_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0010124I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• thin epidermis suprabasal layer_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0009613I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• decreased birth body size_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0009703I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• abnormal coat/hair pigmentation_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0002075I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• decreased subcutaneous adipose tissue amount_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0008844I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal bone marrow morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0002397I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• absent fibroblast proliferation_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>
  http://metadb.riken.jp/0011705I129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstCdk7GtD032B1111Wrst
• abnormal epidermal layer morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001216I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• increased embryonic tissue cell apoptosis_Cdk7<Gt(D032B11)Wrst>/Cdk7<Gt(D032B11)Wrst>
  http://metadb.riken.jp/0013504I129S2SvPasCdk7GtD032B11WrstCdk7GtD032B11WrstCdk7GtD032B11Wrst
• sparse hair_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000416I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• weight loss_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0001263I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal hair follicle bulge morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0009759I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• decreased hair follicle number_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000379I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• kyphosis_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000160I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• decreased small intestinal villus size_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0008142I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal epidermis suprabasal layer morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001233I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• abnormal keratinocyte morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0002655I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• abnormal small intestine crypts of Lieberkuhn morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0004841I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal inner cell mass apoptosis_Cdk7<Gt(D032B11)Wrst>/Cdk7<Gt(D032B11)Wrst>
  http://metadb.riken.jp/0010380I129S2SvPasCdk7GtD032B11WrstCdk7GtD032B11WrstCdk7GtD032B11Wrst
• abnormal trophoblast layer morphology_Cdk7<Gt(D032B11)Wrst>/Cdk7<Gt(D032B11)Wrst>
  http://metadb.riken.jp/0005031I129S2SvPasCdk7GtD032B11WrstCdk7GtD032B11WrstCdk7GtD032B11Wrst
• premature aging_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003786I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• decreased trabecular bone mass_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0010873I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal kidney morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0002135I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• scaly skin_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001192I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• postnatal lethality, complete penetrance_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0011085I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• nephrocalcinosis_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003197I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• decreased hematopoietic stem cell number_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0004810I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal hair follicle morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000377I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal skin morphology_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0002060I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal skin development_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0003941I129S2SvPasC3HC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgKRT5cre1Tak0TgKRT5cre1TakCdk7GtD032B1111Wrst
• thin dermal layer_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0001244I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• abnormal telomere length_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003155I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• alopecia_Cdk7<Gt(D032B11)1.1Wrst>/Cdk7<Gt(D032B11)1.1Wrst>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000414I129SSvPas129S2SvPasC57BL6SJLCdk7GtD032B1111WrstCdk7GtD032B1111WrstTgUBCcreERT21Ejb0Cdk7GtD032B1111WrstTgUBCcreERT21Ejb
• embryonic lethality, complete penetrance_Cdk7<Gt(D032B11)Wrst>/Cdk7<Gt(D032B11)Wrst>
  http://metadb.riken.jp/0011092I129S2SvPasCdk7GtD032B11WrstCdk7GtD032B11WrstCdk7GtD032B11Wrst