Rebecca L. Leshan, et.al., Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance., Nature medicine, 2012, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/22522563

Rebecca L. Leshan, et.al., Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance., Nature medicine, 2012, 18

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased total body fat amount_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0010024I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• hypoactivity_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001402I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• increased body weight_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• decreased circulating thyroxine level_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005478I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• decreased oxygen consumption_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005290I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• increased circulating leptin level_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005669I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• delayed estrous cycle_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0009008I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• decreased circulating thyroxine level_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005478I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased body weight_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased circulating insulin level_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased circulating corticosterone level_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001745I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• decreased oxygen consumption_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005290I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased circulating glucose level_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• reduced female fertility_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001923I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased food intake_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0011939I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• increased circulating corticosterone level_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001745I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased food intake_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0011939I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased circulating glucose level_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• increased total body fat amount_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0010024I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj
• increased circulating leptin level_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0005669I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• hypoactivity_Lepr<tm1.2Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0001402I129S1Sv129X1SvJC57BL6Leprtm12ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1tm1creMgmjNos1Leprtm12Chua
• increased circulating insulin level_Lepr<tm1.1Chua>/Lepr<tm1.2Chua>,Nos1<tm1(cre)Mgmj>/Nos1<+>
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6Leprtm11ChuaLeprtm12ChuaNos1tm1creMgmjNos1Nos1Leprtm12ChuaLeprtm11ChuaNos1tm1creMgmj