C-Y. Chen, et.al., (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD., Cell death and differentiation, 2012, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/22539006

C-Y. Chen, et.al., (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD., Cell death and differentiation, 2012, 19

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(PDGFB-LRRK2*G2019S)32Hlw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5559903

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hypoactivity_Tg(PDGFB-LRRK2*G2019S)32Hlw/?
  http://metadb.riken.jp/0001402FVBNTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32Hlw
• neuron degeneration_Tg(PDGFB-LRRK2*G2019S)32Hlw/?
  http://metadb.riken.jp/0003224FVBNTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32Hlw
• abnormal dopaminergic neuron morphology_Tg(PDGFB-LRRK2*G2019S)32Hlw/?
  http://metadb.riken.jp/0003243FVBNTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32Hlw
• tau protein deposits_Tg(PDGFB-LRRK2*G2019S)32Hlw/?
  http://metadb.riken.jp/0004250FVBNTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32Hlw
• bradykinesia_Tg(PDGFB-LRRK2*G2019S)32Hlw/?
  http://metadb.riken.jp/0005156FVBNTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32Hlw
• abnormal substantia nigra pars compacta morphology_Tg(PDGFB-LRRK2*G2019S)32Hlw/?
  http://metadb.riken.jp/0013219FVBNTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32HlwTgPDGFBLRRK2G2019S32Hlw

class

http://purl.org/net/cito/citesAsAuthority

• Tg(PDGFB-LRRK2*G2019S)32Hlw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5559903