Benedikt. Bosbach, et.al., Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109

http://rdf.ncbi.nlm.nih.gov/pubmed/22652566

Benedikt. Bosbach, et.al., Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Kit<tm4.1Bsm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5442620
• Kit<tm5.1Bsm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5510143

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

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• premature death_Kit<tm5.1Bsm>/Kit<+>
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• increased erythroid progenitor cell number_Kit<tm4.1Bsm>/Kit<+>
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• reddish skin_Kit<tm4.1Bsm>/Kit<+>
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• decreased tumor growth/size_Kit<tm4.1Bsm>/Kit<+>
  http://metadb.riken.jp/0003447I129S1SvC57BL6JFVBNKittm41BsmKitKittm41BsmKit
• increased mean platelet volume_Kit<tm4.1Bsm>/Kit<+>
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• increased hematocrit_Kit<tm4.1Bsm>/Kit<+>
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• enlarged spleen_Kit<tm4.1Bsm>/Kit<+>
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• increased mast cell number_Kit<tm4.1Bsm>/Kit<+>
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• premature death_Kit<tm4.1Bsm>/Kit<+>
  http://metadb.riken.jp/0002083I129S1SvC57BL6JFVBNKittm41BsmKitKittm41BsmKit
• decreased mean corpuscular volume_Kit<tm5.1Bsm>/Kit<+>
  http://metadb.riken.jp/0002591I129S1SvC57BL6JFVBNKittm51BsmKitKitKittm51Bsm
• alopecia_Kit<tm4.1Bsm>/Kit<+>
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• abnormal erythrocyte morphology_Kit<tm4.1Bsm>/Kit<+>
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• interstitial cells of Cajal hyperplasia_Kit<tm5.1Bsm>/Kit<+>
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• small cecum_Kit<tm4.1Bsm>/Kit<+>
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• increased erythrocyte cell number_Kit<tm4.1Bsm>/Kit<+>
  http://metadb.riken.jp/0003131I129S1SvC57BL6JFVBNKittm41BsmKitKittm41BsmKit
• polycythemia_Kit<tm4.1Bsm>/Kit<+>
  http://metadb.riken.jp/0002872I129S1SvC57BL6JFVBNKittm41BsmKitKittm41BsmKit
• lethality, incomplete penetrance_Kit<tm5.1Bsm>/Kit<+>
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• decreased mean corpuscular volume_Kit<tm4.1Bsm>/Kit<+>
  http://metadb.riken.jp/0002591I129S1SvC57BL6JFVBNKittm41BsmKitKittm41BsmKit
• increased gastrointestinal tumor incidence_Kit<tm5.1Bsm>/Kit<+>
  http://metadb.riken.jp/0010279I129S1SvC57BL6JFVBNKittm51BsmKitKitKittm51Bsm
• interstitial cells of Cajal hyperplasia_Kit<tm4.1Bsm>/Kit<+>
  http://metadb.riken.jp/0009537I129S1SvC57BL6JFVBNKittm41BsmKitKittm41BsmKit
• decreased physiological sensitivity to xenobiotic_Kit<tm4.1Bsm>/Kit<+>
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• increased gastrointestinal tumor incidence_Kit<tm4.1Bsm>/Kit<+>
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class

http://purl.org/net/cito/citesAsAuthority

• Kit<tm4.1Bsm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5442620
• Kit<tm5.1Bsm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5510143