Shuichi. Nagashima, et.al., Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death., Arteriosclerosis, thrombosis, and vascular biology, 2012, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/22701022

Shuichi. Nagashima, et.al., Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death., Arteriosclerosis, thrombosis, and vascular biology, 2012, 32

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hmgcr<tm2Ishi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662445

class

http://purl.org/net/cito/citesAsAuthority

• Hmgcr<tm2Ishi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5662445

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating cholesterol level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0005178I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased circulating alanine transaminase level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0002941I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• abnormal liver parenchyma morphology_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0008986I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• abnormal circulating apolipoprotein level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0010332I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• postnatal lethality, incomplete penetrance_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0011086I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• abnormal liver physiology_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000609I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased unsaturated fatty acid level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0005283I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased liver weight_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0002981I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• abnormal circulating lipoprotein level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0010330I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• premature death_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• decreased circulating LDL cholesterol level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000183I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased fatty acid level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0005281I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased circulating free fatty acid level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0001554I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• hepatic steatosis_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0002628I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased circulating phospholipid level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0003980I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased circulating aspartate transaminase level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0005343I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• no abnormal phenotype detected_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>
  http://metadb.riken.jp/0002169I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiHmgcrtm2Ishi
• increased circulating LDL cholesterol level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000182I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• hypoglycemia_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000189I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• pale liver_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000603I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• decreased circulating triglyceride level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0002644I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• weight loss_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0001263I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased circulating bilirubin level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0005344I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• enlarged liver_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000599I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• jaundice_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0000611I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• decreased liver cholesterol level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0010026I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased liver triglyceride level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0009355I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• hepatic necrosis_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0001654I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• liver failure_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0003326I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• decreased circulating cholesterol level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0005179I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi
• increased collagen level_Hmgcr<tm2Ishi>/Hmgcr<tm2Ishi>,Tg(Alb1-cre)1Dlr/0
  http://metadb.riken.jp/0020253I129S7SvEvBrdC57BL6JHmgcrtm2IshiHmgcrtm2IshiTgAlb1cre1Dlr0TgAlb1cre1DlrHmgcrtm2Ishi